Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist
Nicolas Hugues1
Yu Luo2
1.Department of Molecular and Cellular Biosciences,University of Cincinnati,Cincinnati,OH,USA2.Department of Molecular and Cellular Biosciences,University of Cincinnati,Cincinnati,OH,USA;Neuroscience Graduate Program,University of Cincinnati,Cincinnati,OH,USA;Division of Immunobiology,Cincinnati Children's Hospital Medical Center,University of Cincinnati College of Medicine,Cincinnati,OH,USA
摘要：Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).These homeostatic microglia are distinct from activated microglia,the signature of which is highly microenvironment-and cellular context-dependent(Butovsky and Weiner,2018;Paolicelli et al.,2022;Figure 1).
机标关键词：balancegrowthcriticaldiseasedyshomeostaticfactor-beta1healthmicroglial
论文发表日期：2025-10-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 2895-2897 )