Revisiting cerebral endothelial cells in Alzheimer's disease
Amira S.Hanafy
Department of Neurosurgery,University Hospital Bonn,Bonn,Germany
摘要：Alzheimer's disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory functions.In only approximately 5％of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95％of the cases.The amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβ plaques in the parenchyma,an anatomical hallmark of AD.
机标关键词：alzheimercellscerebraldiseaseendothelialrevisiting
论文发表日期：2025-10-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2911-2912 )