Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function
William J.Flerlage1
Mark L.Dell'Acqua2
Brian M.Cox1
Fereshteh S.Nugent1
1.Uniformed Services University of the Health Sciences,Department of Pharmacology and Molecular Therapeutics,Bethesda,MD,USA2.Department of Pharmacology,University of Colorado School of Medicine,Anschutz Medical Campus,Aurora,CO,USA
摘要：There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).
机标关键词：circuitproteinfunctionrolea-kinaseanchoringemergingreward
论文发表日期：2025-10-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2913-2914 )