Beyond neurodegeneration:engineering amyloids for biocatalysis
Andrea Bartolomé-Nafría1
Javier García-Pardo1
Salvador Ventura2
1.Institut de Biotecnologia i de Biomedicina(IBB)and Departament de Bioquímica i Biologia Molecular,Universitat Autònoma de Barcelona,Bellaterra,Barcelona,Spain2.Institut de Biotecnologia i de Biomedicina(IBB)and Departament de Bioquímica i Biologia Molecular,Universitat Autònoma de Barcelona,Bellaterra,Barcelona,Spain;Hospital Universitari Parc Taulí,Institut d'Investigació i Innovació Parc Taulí(I3PT-CERCA),Universitat Autònoma de Barcelona,Sabadell,Spain
摘要：Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet structure.The formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer's disease,Parkinson's disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).However,evidence exists that the amyloid fold is also exploited by nature to perform several functional,nonpathogenic roles across all kingdoms of life.For example,amyloids contribute to biofilm formation in bacteria(Peña-Díaz et al.,2024)or are involved in the regulation of transcription and alternative splicing in humans.As a general trend,amyloids display highly rigid structures with high chemical and mechanical stability,which makes them ideal scaffolds for the design of novel nanostructured materials.
机标关键词：biocatalysisengineeringbeyondneurodamyloidsdegeneration
论文发表日期：2025-10-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2915-2916 )