Understanding the link between type 2 diabetes mellitus and Parkinson's disease:role of brain insulin resistance
Theodora Ntetsika1
Sergiu-Bogdan Catrina2
Ioanna Markaki3
1.Department of Clinical Neuroscience,Karolinska Institute,Stockholm,Sweden;Department of Neurology,Karolinska University Hospital,Stockholm,Sweden2.Department of Molecular Medicine and Surgery,Karolinska Institute,Stockholm,Sweden;Center for Diabetes,Academic Specialist Center,Stockholm,Sweden3.Department of Clinical Neuroscience,Karolinska Institute,Stockholm,Sweden;Center for Neurology,Academic Specialist Center,Stockholm,Sweden
摘要：Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden.Epidemiological data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular mechanisms.Impaired insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson's disease through the dysregulation of several pathological processes.The contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson's disease,with emphasis on brain insulin resistance,is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed.
机标关键词：parkinsoninsulinbetweenbrainrolelinkdiabetesdisease
论文发表日期：2025-11-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：11( 3113-3123 )
英文信息