Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system
Marta García-Juan1
Mario Villa2
Irene Benito-Cuesta3
Lara Ordóñez-Gutiérrez4
Francisco Wandosell5
1.Centro de Biología Molecular"Severo Ochoa"(CSIC-UAM),Nicolas Cabrera 1,Universidad Autónoma de Madrid,Madrid,Spain2.Fisiología Animal,Departamento de Biología,Facultad de Ciencias,Universidad Autónoma de Madrid,Madrid,Spain3.Department of Clinical Neuroscience,CMM Karolinska Universitetssjukhuset Solna,Stockholm,Sweden4.Centro de Biología Molecular"Severo Ochoa"(CSIC-UAM),Nicolas Cabrera 1,Universidad Autónoma de Madrid,Madrid,Spain;Departamento de Bioquímica y Biología Molecular,Universidad Complutense de Madrid,Madrid,Spain;Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED),Madrid,Spain5.Centro de Biología Molecular"Severo Ochoa"(CSIC-UAM),Nicolas Cabrera 1,Universidad Autónoma de Madrid,Madrid,Spain;Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED),Madrid,Spain
摘要：Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and function.This cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino acids.This process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been characterized based on their dynamic,mechanism of action,target substrates,and protein markers.Some of them are macroautophagy(hereafter called"autophagy"),microautophagy,and chaperone-mediated autophagy(Fleming et al.,2022).
机标关键词：balancecentralsystemampk-mtorc1autophagynervousreassessing
论文发表日期：2025-11-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 3209-3210 )