Misfolded amyloid-beta conformational variants(strains)as drivers of Alzheimer's disease neuropathology
Salvatore Saieva1
Rodrigo Morales2
1.Department of Neurology,The University of Texas Health Science Center at Houston,Houston,TX,USA2.Department of Neurology,The University of Texas Health Science Center at Houston,Houston,TX,USA;Centro Integrativo de Biologia y Quimica Aplicada(CIBQA),Universidad Bernardo O'Higgins,Santiago,Chile
摘要：Pathological and clinical variability in Alzheimer's disease(AD):AD is clinically characterized by progressive memory loss and cognitive impairment.From a pathological point of view,the main features of AD are the deposition of amyloid plaques(composed of amyloid-beta,Aβ)and neurofibrillary tangles containing hyperphosphorylated Tau in the brain,accompanied by neuronal and synaptic loss,neuroinflammation and brain atrophy(Jellinger,2022).Regardless of these common traits,growing evidence shows increased heterogeneity in the brain of AD patients considering both clinical manifestations and pathological features.Mounting evidence points to the variable conformations that misfolded Aβ can acquire(referred to as"Aβ strains")as the source of this pathological and clinical variability.The existence of Aβ strains is relevant as they may also predict prognosis and responses to treatments.The concept of Aβ strains is analogous to that coined for infectious prion strains,which are further defined below(Jellinger,2022).
机标关键词：alzheimeramyloid-betaconformationaldiseasedriversmisfoldedneuropathologystrains
论文发表日期：2025-11-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 3219-3220 )