Optimizing non-invasive vagus nerve stimulation for treatment in stroke
Sheharyar S.Baig1
Samantha Dorney1
Mudasar Aziz2
Simon M.Bell1
Ali N.Ali1
Li Su1
Jessica N.Redgrave1
Arshad Majid1
1.Sheffield Institute for Translational Neuroscience,Department of Neuroscience,University of Sheffield,Sheffield,UK2.Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust,Doncaster,UK
摘要：Stroke remains a leading cause of long-term disability worldwide.There is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological recovery.Transcutaneous vagus nerve stimulation has been demonstrated to show potential therapeutic effects in both acute and chronic stroke.However,previously published research has only investigated a narrow range of stimulation settings and indications.In this review,we detail the ongoing studies of transcutaneous vagus nerve stimulation in stroke through systematic searches of registered clinical trials.We summarize the upcoming clinical trials of transcutaneous vagus nerve stimulation in stroke,highlighting their indications,parameter settings,scope,and limitations.We further explore the challenges and barriers associated with the implementation of transcutaneous vagus nerve stimulation in acute stroke and stroke rehabilitation,focusing on critical aspects such as stimulation settings,target groups,biomarkers,and integration with rehabilitation interventions.
机标关键词：strokenervenon-invasiveoptimizingstimulationtreatmentvagus
论文发表日期：2025-12-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 3388-3399 )
英文信息