Bidirectional causality of physical exercise in retinal neuroprotection
Stephen K.Agadagba1
Suk-yu Yau2
Ying Liang1
Kristine Dalton3
Benjamin Thompson3
1.Center for Eye and Vision Research Limited,17W,Hong Kong Science Park,Hong Kong Special Administrative Region,China2.Center for Eye and Vision Research Limited,17W,Hong Kong Science Park,Hong Kong Special Administrative Region,China;Department of Rehabilitation Sciences,The Hong Kong Polytechnic University,Hong Kong Special Administrative Region,China3.Center for Eye and Vision Research Limited,17W,Hong Kong Science Park,Hong Kong Special Administrative Region,China;School of Optometry and Vision Science,University of Waterloo,Waterloo,ON,Canada
摘要：Physical exercise is recognized as an effective intervention to improve mood,physical performance,and general well-being.It achieves these benefits through cellular and molecular mechanisms that promote the release of neuroprotective factors.Interestingly,reduced levels of physical exercise have been implicated in several central nervous system diseases,including ocular disorders.Emerging evidence has suggested that physical exercise levels are significantly lower in individuals with ocular diseases such as glaucoma,age-related macular degeneration,retinitis pigmentosa,and diabetic retinopathy.Physical exercise may have a neuroprotective effect on the retina.Therefore,the association between reduced physical exercise and ocular diseases may involve a bidirectional causal relationship whereby visual impairment leads to reduced physical exercise and decreased exercise exacerbates the development of ocular disease.In this review,we summarize the evidence linking physical exercise to eye disease and identify potential mediators of physical exercise-induced retinal neuroprotection.Finally,we discuss future directions for preclinical and clinical research in exercise and eye health.
机标关键词：physicalbidirectionalcausalityexerciseneuroprotectionretinal
论文发表日期：2025-12-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：16( 3400-3415 )
英文信息