Functional abnormalities of the glymphatic system in cognitive disorders
Wuyue Shentu1
Qi Kong2
Yier Zhang1
Wenyao Li3
Qiulu Chen4
Sicheng Yan5
Junjun Wang2
Qilun Lai2
Qi Xu6
Song Qiao2
1.The Second Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou,Zhejiang Province,China2.Department of Neurology,Zhejiang Hospital,Hangzhou,Zhejiang Province,China3.Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou,Zhejiang Province,China4.Department of Neurology,Zhejiang Medical & Health Group Hangzhou Hospital,Hangzhou,Zhejiang Province,China5.Department of Neurology,Liuzhou People's Hospital,Liuzhou,Guangxi Zhuang Autonomous Region,China6.Department of Radiology,Zhejiang Hospital,Hangzhou,Zhejiang Province,China
摘要：Various pathological mechanisms represent distinct therapeutic targets for cognitive disorders,but a balance between clearance and production is essential for maintaining the stability of the brain's internal environment.Thus,the glymphatic system may represent a common pathway by which to address cognitive disorders.Using the established model of the glymphatic system as our foundation,this review disentangles and analyzes the components of its clearance mechanism,including the initial inflow of cerebrospinal fluid,the mixing of cerebrospinal fluid with interstitial fluid,and the outflow of the mixed fluid and the clearance.Each section summarizes evidence from experimental animal models and human studies,highlighting the normal physiological properties of key structures alongside their pathological manifestations in cognitive disorders.The same pathologic manifestations of different cognitive disorders appearing in the glymphatic system and the same upstream influences are main points of interest of this review.We conclude this article by discussing new findings and outlining the limitations identified in current research progress.
机标关键词：cognitivesystemabnormalitiesdisordersfunctionalglymphatic
论文发表日期：2025-12-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 3430-3447 )
英文信息