Potential of ultrasound stimulation and sonogenetics in vision restoration:a narrative review
Jie Ji1
Chen Gong2
Gengxi Lu2
Junhang Zhang2
Baoqiang Liu1
Xunan Liu1
Junhao Lin3
Patrick Wang4
Biju B.Thomas5
Mark S.Humayun2
Qifa Zhou2
1.Department of Biomedical Engineering,University of Southern California,Los Angeles,CA,USA2.Department of Biomedical Engineering,University of Southern California,Los Angeles,CA,USA;USC Roski Eye Institute,Keck School of Medicine of University of Southern California,Los Angeles,CA,USA3.Thomas Lord Department of Computer Science,University of Southern California,Los Angeles,CA,USA4.Harvard Westlake School,Studio City,CA,USA5.USC Roski Eye Institute,Keck School of Medicine of University of Southern California,Los Angeles,CA,USA
摘要：Vision restoration presents a considerable challenge in the realm of regenerative medicine,while recent progress in ultrasound stimulation has displayed potential as a non-invasive therapeutic approach.This narrative review offers a comprehensive overview of current research on ultrasound-stimulated neuromodulation,emphasizing its potential as a treatment modality for various nerve injuries.By examining of the efficacy of different types of ultrasound stimulation in modulating peripheral and optic nerves,we can delve into their underlying molecular mechanisms.Furthermore,the review underscores the potential of sonogenetics in vision restoration,which involves leveraging pharmacological and genetic manipulations to inhibit or enhance the expression of related mechanosensitive channels,thereby modulating the strength of the ultrasound response.We also address how methods such as viral transcription can be utilized to render specific neurons or organs highly responsive to ultrasound,leading to significantly improved therapeutic outcomes.
机标关键词：ultrasoundvisionreviewnarrativepotentialrestorationsonogeneticsstimulation
论文发表日期：2025-12-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：16( 3501-3516 )
英文信息