Adiponectin as a potential mediator of the pro-cognitive effects of physical exercise on Alzheimer's disease
Hui-Hui Guo1
Hai-Ning Ou2
Jia-Sui Yu3
Julia Macedo Rosa3
Douglas Affonso Formolo3
Tong Cheng3
Suk-Yu Yau3
Hector Wing Hong Tsang4
1.Department of Rehabilitation Medicine,The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou,Guangdong Province,China;Department of Rehabilitation Medicine,Shaoxing People's Hospital,Shaoxing,Zhejiang Province,China2.Department of Rehabilitation Medicine,The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou,Guangdong Province,China;Department of Rehabilitation,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou,Guangdong Province,China;The Second Institute of Clinical Medicine,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong Province,China3.Department of Rehabilitation Sciences,The Hong Kong Polytechnic University,Hong Kong Special Administrative Region,China;Mental Health Research Center,The Hong Kong Polytechnic University,Hong Kong Special Administrative Region,China4.Department of Rehabilitation Medicine,The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou,Guangdong Province,China;Department of Rehabilitation Sciences,The Hong Kong Polytechnic University,Hong Kong Special Administrative Region,China;Mental Health Research Center,The Hong Kong Polytechnic University,Hong Kong Special Administrative Region,China
摘要：Alzheimer's disease is the primary cause of dementia and imposes a significant socioeconomic burden globally.Physical exercise,as an effective strategy for improving general health,has been largely reported for its effectiveness in slowing neurodegeneration and increasing brain functional plasticity,particularly in aging brains.However,the underlying mechanisms of exercise in cognitive aging remain largely unclear.Adiponectin,a cell-secreted protein hormone,has recently been found to regulate synaptic plasticity and mediate the antidepressant effects of physical exercise.Studies on the neuroprotective effects of adiponectin have revealed potential innovative treatments for Alzheimer's disease.Here,we reviewed the functions of adiponectin and its receptor in the brains of human and animal models of cognitive impairment.We summarized the role of adiponectin in Alzheimer's disease,focusing on its impact on energy metabolism,insulin resistance,and inflammation.We also discuss how exercise increases adiponectin secretion and its potential benefits for learning and memory.Finally,we highlight the latest research on chemical compounds that mimic exercise-enhanced secretion of adiponectin and its receptor in Alzheimer's disease.
机标关键词：adiponectinalzheimermediatorphysicaldiseaseeffectsexercisepotential
论文发表日期：2026-01-30
在线出版日期：2025-12-11（本平台首次上网日期，不代表文献的发表时间）
页数：11( 96-106 )
英文信息