Neuronal plasticity and its role in Alzheimer's disease and Parkinson's disease
Israt Jahan1
Mohammad Harun-Ur-Rashid2
Md.Aminul Islam1
Farhana Sharmin3
Soad K.Al Jaouni4
Abdullah M.Kaki5
Samy Selim6
1.Genetic Engineering and Biotechnology Research Laboratory(GEBRL),Centre for Advanced Research in Sciences(CARS),University of Dhaka,Dhaka,Bangladesh2.Department of Chemistry,International University of Business Agriculture and Technology(IUBAT),Sector 10,Uttara Model Town,Dhaka,Bangladesh3.Department of Anatomy,Shaheed Suhrawardy Medical College,Dhaka,Bangladesh4.Department of Hematology/Oncology,Faculty of Medicine,King Abdulaziz University,Jeddah,Saudi Arabia5.Department of Anesthesia and Pain Medicine,Faculty of Medicine,King Abdulaziz University,Jeddah,Saudi Arabia6.Department of Clinical Laboratory Sciences,College of Applied Medical Sciences,Jouf University,Sakaka,Saudi Arabia
摘要：Neuronal plasticity,the brain's ability to adapt structurally and functionally,is essential for learning,memory,and recovery from injuries.In neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease,this plasticity is disrupted,leading to cognitive and motor deficits.This review explores the mechanisms of neuronal plasticity and its effect on Alzheimer's disease and Parkinson's disease.Alzheimer's disease features amyloid-beta plaques and tau tangles that impair synaptic function,while Parkinson's disease involves the loss of dopaminergic neurons affecting motor control.Enhancing neuronal plasticity offers therapeutic potential for these diseases.A systematic literature review was conducted using databases such as PubMed,Scopus,and Google Scholar,focusing on studies of neuronal plasticity in Alzheimer's disease and Parkinson's disease.Data synthesis identified key themes such as synaptic mechanisms,neurogenesis,and therapeutic strategies,linking molecular insights to clinical applications.Results highlight that targeting synaptic plasticity mechanisms,such as long-term potentiation and long-term depression,shows promise.Neurotrophic factors,advanced imaging techniques,and molecular tools(e.g.,clustered regularly interspaced short palindromic repeats and optogenetics)are crucial in understanding and enhancing plasticity.Current therapies,including dopamine replacement,deep brain stimulation,and lifestyle interventions,demonstrate the potential to alleviate symptoms and improve outcomes.In conclusion,enhancing neuronal plasticity through targeted therapies holds significant promise for treating neurodegenerative diseases.Future research should integrate multidisciplinary approaches to fully harness the therapeutic potential of neuronal plasticity in Alzheimer's disease and Parkinson's disease.
机标关键词：alzheimerparkinsonrolediseaseneuronalplasticity
论文发表日期：2026-01-30
在线出版日期：2025-12-11（本平台首次上网日期，不代表文献的发表时间）
页数：19( 107-125 )
英文信息