Cerebellar microglia:On the edge between neuroinflammation and neuroregulation
Marina S.Dukhinova1
Jingwen Guo2
Enwei Shen2
Wanting Liu3
Wanqi Huang3
Ying Shen3
Luxi Wang4
1.Center for Brain Health,the Fourth Affiliated Hospital of School of Medicine,and International School of Medicine,International Institute of Medicine,Zhejiang University,Yiwu,Zhejiang Province,China2.Department of Physiology and Department of Psychiatry,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China3.Center for Brain Health,the Fourth Affiliated Hospital of School of Medicine,and International School of Medicine,International Institute of Medicine,Zhejiang University,Yiwu,Zhejiang Province,China;Department of Physiology and Department of Psychiatry,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China4.Center for Brain Health,the Fourth Affiliated Hospital of School of Medicine,and International School of Medicine,International Institute of Medicine,Zhejiang University,Yiwu,Zhejiang Province,China;Department of Physiology,School of Basic Medical Sciences,Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China
摘要：The cerebellum is receiving increasing attention for its cognitive,emotional,and social functions,as well as its unique metabolic profiles.Cerebellar microglia exhibit specialized and highly immunogenic phenotypes under both physiological and pathological conditions.These immune cells communicate with intrinsic and systemic factors and contribute to the structural and functional compartmentalization of the cerebellum.In this review,we discuss the roles of microglia in the cerebellar microenvironment,neuroinflammation,cerebellar adaptation,and neuronal activity,the associated molecular and cellular mechanisms,and potential therapeutic strategies targeting cerebellar microglia in the context of neuroinflammation.Future directions and unresolved questions in this field are further highlighted,particularly regarding therapeutic interventions targeting cerebellar microglia,functional mechanisms and activities of microglia in the cerebellar circuitry,neuronal connectivity,and neurofunctional outcomes of their activity.Cerebellar morphology and neuronal performance are influenced by both intrinsic and systemic factors that are actively monitored by microglia in both healthy and diseased states.Under pathological conditions,local subsets of microglia exhibit diverse responses to the altered microenvironment that contribute to the structural and functional compartmentalization of the cerebellum.Microglia in the cerebellum undergo early maturation during the embryonic stage and display specialized,highly immunogenic phenotypes.In summary,cerebellar microglia have the capacity to serve as regulatory tools that influence outcomes across a wide range of neurological and systemic conditions,including neurodevelopmental,neurodegenerative,metabolic,and stress-related disorders.
机标关键词：betweenedgecerebellarinflammationmicroglianeuroregulation
论文发表日期：2026-01-30
在线出版日期：2025-12-11（本平台首次上网日期，不代表文献的发表时间）
页数：17( 156-172 )
英文信息