Investigation of epilepsy-related genes in a Drosophila model
Xiaochong Qu1
Xiaodan Lai1
Mingfeng He1
Jinyuan Zhang2
Binbin Xiang3
Chuqiao Liu1
Ruina Huang1
Yiwu Shi1
Jingda Qiao1
1.Department of Neurology,Institute of Neuroscience,Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China,the Second Affiliated Hospital,Guangzhou Medical University,Guangzhou,Guangdong Province,China2.School of Health Management,Guangzhou Medical University,Guangzhou,Guangdong Province,China3.The First Clinical Medicine School of Guangzhou Medical University,Guangzhou,Guangdong Province,China
摘要：Complex genetic architecture is the major cause of heterogeneity in epilepsy,which poses challenges for accurate diagnosis and precise treatment.A large number of epilepsy candidate genes have been identified from clinical studies,particularly with the widespread use of next-generation sequencing.Validating these candidate genes is emerging as a valuable yet challenging task.Drosophila serves as an ideal animal model for validating candidate genes associated with neurogenetic disorders such as epilepsy,due to its rapid reproduction rate,powerful genetic tools,and efficient use of ethological and electrophysiological assays.Here,we systematically summarize the advantageous techniques of the Drosophila model used to investigate epilepsy genes,including genetic tools for manipulating target gene expression,ethological assays for seizure-like behaviors,electrophysiological techniques,and functional imaging for recording neural activity.We then introduce several typical strategies for identifying epilepsy genes and provide new insights into gene-gene interactions in epilepsy with polygenic causes.We summarize well-established precision medicine strategies for epilepsy and discuss prospective treatment options,including drug therapy and gene therapy for genetic epilepsy based on the Drosophila model.Finally,we also address genetic counseling and assisted reproductive technology as potential approaches for the prevention of genetic epilepsy.
机标关键词：genesmodeldrosophilaepilepsyinvestigationrelated
论文发表日期：2026-01-30
在线出版日期：2025-12-11（本平台首次上网日期，不代表文献的发表时间）
页数：17( 195-211 )
英文信息