Metabolic reprogramming of astrocytes:Emerging roles of lactate
Zeyu Liu1
Yijian Guo2
Ying Zhang1
Yulei Gao1
Bin Ning3
1.Central Hospital Affiliated to Shandong First Medical University,Shandong First Medical University & Shandong Academy of Medical Sciences,Jinan,Shandong Province,China2.Department of Spinal Surgery,Jinan Central Hospital,Cheeloo College of Medicine,Shandong University,Jinan,Shandong Province,China3.Central Hospital Affiliated to Shandong First Medical University,Shandong First Medical University & Shandong Academy of Medical Sciences,Jinan,Shandong Province,China;Department of Spinal Surgery,Jinan Central Hospital,Cheeloo College of Medicine,Shandong University,Jinan,Shandong Province,China
摘要：Lactate serves as a key energy metabolite in the central nervous system,facilitating essential brain functions,including energy supply,signaling,and epigenetic modulation.Moreover,it links epigenetic modifications with metabolic reprogramming.Nonetheless,the specific mechanisms and roles of this connection in astrocytes remain unclear.Therefore,this review aims to explore the role and specific mechanisms of lactate in the metabolic reprogramming of astrocytes in the central nervous system.The close relationship between epigenetic modifications and metabolic reprogramming was discussed.Therapeutic strategies for targeting metabolic reprogramming in astrocytes in the central nervous system were also outlined to guide future research in central nervous system diseases.In the nervous system,lactate plays an essential role.However,its mechanism of action as a bridge between metabolic reprogramming and epigenetic modifications in the nervous system requires future investigation.The involvement of lactate in epigenetic modifications is currently a hot research topic,especially in lactylation modification,a key determinant in this process.Lactate also indirectly regulates various epigenetic modifications,such as N6-methyladenosine,acetylation,ubiquitination,and phosphorylation modifications,which are closely linked to several neurological disorders.In addition,exploring the clinical applications and potential therapeutic strategies of lactic acid provides new insights for future neurological disease treatments.
机标关键词：metaboliclactateastrocytesemergingreprogrammingroles
论文发表日期：2026-02-28
在线出版日期：2025-12-09（本平台首次上网日期，不代表文献的发表时间）
页数：12( 421-432 )
英文信息