What is the pathophysiology of inflammation-induced cortical injury in the perinatal brain?
Sharmony B.Kelly1
Alistair J.Gunn2
Rodney W.Hunt3
Robert Galinsky1
1.The Ritchie Centre,Hudson Institute of Medical Research,Melbourne,VIC,Australia;Department of Obstetrics and Gynaecology,Monash University,Melbourne,VIC,Australia2.Department of Physiology,The University of Auckland,Auckland,New Zealand3.The Ritchie Centre,Hudson Institute of Medical Research,Melbourne,VIC,Australia;Monash Newborn,Monash Children's Hospital,Melbourne,Australia
摘要：Perinatal exposure to infection/inflammation is highly associated with neural injury,and subsequent impaired cortical growth,disturbances in neuronal connectivity,and impaired neurodevelopment.However,our understanding of the pathophysiological substrate underpinning these changes in brain structure and function is limited.The objective of this review is to summarize the growing evidence from animal trials and human cohort studies that suggest exposure to infection/inflammation during the perinatal period promotes regional impairments in neuronal maturation and function,including loss of high-frequency electroencephalographic activity,and reduced growth and arborization of cortical dendrites and dendritic spines resulting in reduced cortical volume.These inflammation-induced disturbances to neuronal structure and function are likely to underpin subsequent disturbances to cortical development and connectivity in fetuses and/or newborns exposed to infection/inflammation during the perinatal period,leading,in the long term,to impaired neurodevelopment.The combined use of early electroencephalography monitoring with neuroimaging techniques that enable detailed evaluation of brain microstructure,and the use of therapeutics that successfully target systemic and central nervous system inflammation could provide an effective strategy for early detection and therapeutic intervention.
机标关键词：whatbraincorticalinducedinflammationinjurypathophysiologyperinatal
论文发表日期：2026-02-28
在线出版日期：2025-12-09（本平台首次上网日期，不代表文献的发表时间）
页数：4( 502-505 )
英文信息