Neuromodulation technologies improve functional recovery after brain injury:From bench to bedside
Mei Liu1
Yijing Meng1
Siguang Ouyang1
Meng'ai Zhai2
Likun Yang1
Yang Yang1
Yuhai Wang1
1.Department of Neurosurgery,Wuxi Clinical College of Anhui Medical University(The 904th Hospital of PLA),Wuxi,Jiangsu Province,China2.Department of Neurosurgery,The 904th Hospital of PLA,Jiangnan University,Wuxi,Jiangsu Province,China
摘要：Spontaneous recovery frequently proves maladaptive or insufficient because the plasticity of the injured adult mammalian central nervous system is limited.This limited plasticity serves as a primary barrier to functional recovery after brain injury.Neuromodulation technologies represent one of the fastest-growing fields in medicine.These techniques utilize electricity,magnetism,sound,and light to restore or optimize brain functions by promoting reorganization or long-term changes that support functional recovery in patients with brain injury.Therefore,this review aims to provide a comprehensive overview of the effects and underlying mechanisms of neuromodulation technologies in supporting motor function recovery after brain injury.Many of these technologies are widely used in clinical practice and show significant improvements in motor function across various types of brain injury.However,studies report negative findings,potentially due to variations in stimulation protocols,differences in observation periods,and the severity of functional impairments among participants across different clinical trials.Additionally,we observed that different neuromodulation techniques share remarkably similar mechanisms,including promoting neuroplasticity,enhancing neurotrophic factor release,improving cerebral blood flow,suppressing neuroinflammation,and providing neuroprotection.Finally,considering the advantages and disadvantages of various neuromodulation techniques,we propose that future development should focus on closed-loop neural circuit stimulation,personalized treatment,interdisciplinary collaboration,and precision stimulation.
机标关键词：technologiesrecoveryimprovebrainafterfrombedsidebench
论文发表日期：2026-02-28
在线出版日期：2025-12-09（本平台首次上网日期，不代表文献的发表时间）
页数：15( 506-520 )
英文信息