Role of mitophagy in spinal cord ischemia-reperfusion injury
Yanni Duan
Fengguang Yang
Yibao Zhang
Mingtao Zhang
Yujun Shi
Yun Lang
Hongli Sun
Xin Wang
Hongyun Jin
Xuewen Kang
Department of Orthopedics,The Second Hospital of Lanzhou University,Lanzhou,Gansu Province,China;The Second Clinical Medical School,Lanzhou University,Lanzhou,Gansu Province,China;Orthopaedics Key Laboratory of Gansu Province,The Second Hospital of Lanzhou University,Lanzhou,Gansu Province,China
摘要：Spinal cord ischemia-reperfusion injury,a severe form of spinal cord damage,can lead to sensory and motor dysfunction.This injury often occurs after traumatic events,spinal cord surgeries,or thoracoabdominal aortic surgeries.The unpredictable nature of this condition,combined with limited treatment options,poses a significant burden on patients,their families,and society.Spinal co rd ischemia-reperfusion injury leads to reduced neuronal regenerative capacity and complex pathological processes.In contrast,mitophagy is crucial for degrading damaged mitochondria,thereby supporting neuronal metabolism and energy supply.However,while moderate mitophagy can be beneficial in the context of spinal cord ischemia-reperfusion injury,excessive mitophagy may be detrimental.Therefore,this review aims to investigate the potential mechanisms and regulators of mitophagy involved in the pathological processes of spinal cord ischemia-reperfusion injury.The goal is to provide a comprehensive understanding of recent advancements in mitophagy related to spinal cord ischemia-reperfusion injury and clarify its potential clinical applications.
机标关键词：ischemiacordroleinjurymitophagyreperfusionspinal
论文发表日期：2026-02-28
在线出版日期：2025-12-09（本平台首次上网日期，不代表文献的发表时间）
页数：14( 598-611 )
英文信息