Novel insights into non-coding RNAs and their role in hydrocephalus
Zhiyue Cui1
Jian He2
An Li3
Junqiang Wang3
Yijian Yang3
Kaiyue Wang3
Zhikun Liu3
Qian Ouyang4
Zhangjie Su5
Pingsheng Hu6
Gelei Xiao3
1.Department of Diagnostic Radiology,The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University/Hunan Cancer Hospital,Changsha,Hunan Province,China;Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;Diagnosis and Treatment Center for Hydrocephalus,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan Province,China2.Department of Pediatrics,Xiangya Hospital,Central South University,Changsha,Hunan Province,China3.Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;Diagnosis and Treatment Center for Hydrocephalus,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan Province,China4.Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;Diagnosis and Treatment Center for Hydrocephalus,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha,Hunan Province,China;Department of Neurosurgery,Zhuzhou Hospital,Central South University Xiangya School of Medicine,Zhuzhou,Hunan Province,China5.Department of Neurosurgery,Addenbrooke's Hospital,Cambridge University Hospitals NHS Foundation Trust,Hills Road,Cambridge,UK6.Department of Diagnostic Radiology,The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University/Hunan Cancer Hospital,Changsha,Hunan Province,China
摘要：A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation.This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiological mechanisms underlying hydrocephalus,one of the most common neurological conditions worldwide.In this review,we first outline the basic concepts and incidence of hydrocephalus along with the limitations of existing treatments for this condition.Then,we outline the definition,classification,and biological role of non-coding RNAs.Subsequently,we analyze the roles of non-coding RNAs in the formation of hydrocephalus in detail.Specifically,we have focused on the potential significance of non-coding RNAs in the pathophysiology of hydrocephalus,including glymphatic pathways,neuroinflammatory processes,and neurological dysplasia,on the basis of the existing evidence.Lastly,we review the potential of non-coding RNAs as biomarkers of hydrocephalus and for the creation of innovative treatments.
机标关键词：insightsrolernasnovelhydrocephalusintonon-codingtheir
论文发表日期：2026-02-28
在线出版日期：2025-12-09（本平台首次上网日期，不代表文献的发表时间）
页数：12( 636-647 )
英文信息