Roles of central nervous system resident and recruited macrophages in the brain barrier system
Ze Liu1
Teng Cheng1
Hongtian Dong1
Dingya Sun1
Yan Wang2
Jiayan Li3
Zhongwang Yu1
Li Cao1
1.Institute of Neuroscience Key Laboratory of Molecular Neurobiology of Ministry of Education and the Collaborative Innovation Center for Brain Science SMMU,Shanghai,China2.Department of Pharmacy,Shanghai Baoshan District Wusong Central Hospital(Zhongshan Hospital Wusong Branch,Fudan University),Shanghai,China3.Neurovascular Center,Changhai Hospital SMMU,Shanghai,China
摘要：Macrophages in the brain barrier system include microglia in the brain parenchyma,border-associated macrophages at the brain's borders,and recruited macrophages.They are responsible for neural development,maintenance of homeostasis,and orchestrating immune responses.With the rapid exploitation and development of new technologies,there is a deeper understanding of macrophages in the brain barrier system.Here we review the origin,development,important molecules,and functions of macrophages,mainly focusing on microglia and border-associated macrophages.We also highlight some advances in single-cell sequencing and significant cell markers.We anticipate that more advanced methods will emerge to study resident and recruited macrophages in the future,opening new horizons for neuroimmunology and related peripheral immune fields.
机标关键词：barriercentralsystembrainmacrophagesnervousrecruitedresident
论文发表日期：2026-03-30
在线出版日期：2026-03-18（本平台首次上网日期，不代表文献的发表时间）
页数：14( 855-868 )
英文信息