Schizophrenia:Genetics,neurological mechanisms,and therapeutic approaches
Debbie Xiu En Lim1
Shi Yun Yeo2
Zhen You Ashley Chia2
Aaron Zefrin Fernandis2
Jimmy Lee3
John Jia En Chua4
1.Department of Physiology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore;LSI Neurobiology Programme,National University of Singapore,Singapore;Healthy Longevity Translational Research Program,Yong Loo Lin School of Medicine,National University of Singapore,Singapore;Quantitative Biosciences,MSD International GmbH,Singapore Branch,Singapore2.Quantitative Biosciences,MSD International GmbH,Singapore Branch,Singapore3.North Region,Institute of Mental Health,Singapore;Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore4.Department of Physiology,Yong Loo Lin School of Medicine,National University of Singapore,Singapore;LSI Neurobiology Programme,National University of Singapore,Singapore;Healthy Longevity Translational Research Program,Yong Loo Lin School of Medicine,National University of Singapore,Singapore;Institute of Molecular and Cell Biology,Agency for Science,Technology and Research(A*STAR),Singapore
摘要：Schizophrenia is a complex psychiatric disorder marked by positive and negative symptoms,leading to mood disturbances,cognitive impairments,and social withdrawal.While anti-psychotic medications remain the cornerstone of treatment,they often fail to fully address certain symptoms.Additionally,treatment-resistant schizophrenia,affecting 30%-40%of patients,remains a substantial clinical challenge.Positive,negative symptoms and cognitive impairments have been linked to disruptions in the glutamatergic,serotonin,GABAergic,and muscarinic pathways in the brain.Recent advances using genome-wide association study and other approaches have uncovered a significant number of new schizophrenia risk genes that uncovered new,and reinforced prior,concepts on the genetic and neurological underpinnings of schizophrenia,including abnormalities in synaptic function,immune processes,and lipid metabolism.Concurrently,new therapeutics targeting different modalities,which are expected to address some of the limitations of anti-psychotic drugs currently being offered to patients,are currently being evaluated.Collectively,these efforts provide new momentum for the next phase of schizophrenia research and treatment.
机标关键词：schizophreniaapproachesgeneticsmechanismsneurologicaltherapeutic
论文发表日期：2026-03-30
在线出版日期：2026-03-18（本平台首次上网日期，不代表文献的发表时间）
页数：15( 1089-1103 )
英文信息