Secretory autophagy in neurons:More than throwing out the trash?
Alexander Veh
Patrick Lüningschrör
Institute of Clinical Neurobiology,University Hospital Würzburg,Würzburg,Germany
摘要：Autophagy is well-known for delivering cargo materials to lysosomes for proteolytic digestion.Recently,autophagy has emerged as a key mechanism in unconventional protein secretion(UPS). This perspective introduces unconventional secretion pathways,focusing on secretory autophagy and its role in secreting protein aggregates associated with neurodegenerative disorders. We also explore additional neuronal functions of secretory autophagy beyond the release of protein aggregates. We propose autophagosomes as transport organelles that deliver cargo material directly from the endoplasmatic reticulum (ER) to the plasma membrane rather than solely to lysosomes.
机标关键词：thanmoreautophagyneuronssecretorythrowingtrash
论文发表日期：2026-03-30
在线出版日期：2026-03-18（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1108-1109 )