Pharmacokinetics, Biodistribution and Elimination of Recombinant Human Homoserine Thymosin in Rats and Mice
MA Jian-xiu
LEI Ze-lin
ZHONG Jian-bing
MA Yan-qing
JIN Long
摘要：Objective:To study the pharmacokinetic,distribution and elimination properties of rhT α 1 after intravenous (i.v.) and subcutaneous (s.c.) injection in mice and rats.Methods:Competition ELISA was used for testing drug concentration in serum,urine,bile and tissue after administration of rhT α 1 in mice (0.16,0.5,2.5 mg/kg) and rats (0.32,1,5 mg/kg).Pharmacokinetic parameters were calculated by WinNolin software.Results:Absorption of rhTα 1 is rapid in both mice and rats after s.c.administration.The pharmacokinetics in mice are characterized by linear,T1/2 showed a prolongation with increasing dose,1.10,1.35,and 1.50 h corresponding to 0.32,1 and 5 mg/kg respectively,but in rats Ti/2 showed no difference among doses.AUC0-∞ showed a clear increase with increasing doses in mice (904.18,2998.83,and 19001.82 h*ng/rnL) and in rats (1327.56 ± 237.00,2924.53 ± 685.14,and 35286.26 ± 5999.58 h*ng/mL) After i.v.administration of 1 mg/kg rhTα1 in mice,the drug is seen distributed in most organs,the thymus/serum exposure ratio was higher than others at the 1 and 2 h,the accumulative urinary excretion of primary drug was 3297％ ± 15.85％ within 6 h.Conclusion:The results indicate that rapid absorption,extensive distribution and quick renal excretion were the basic kinetic characteristics of rhTαl after s.c.and i.v.administration.
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分类号：R96(药理学)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 114-128 )
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