SIRT1 Protects Cortical Neurons
from Shear Stress Induced Mechanical Injury
WEI Song
LIU Mei-li
LI Ping
ZHOU Gang
FAN Yu-bo
1.Key Lab for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China2.Key Lab for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China3.Key Lab for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China4.Key Lab for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China5.Key Lab for Biomechanics and Mechanobiology of Ministry of Education,School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China
摘要：Emerging evidence implicates that SIRT1, one of NAD-dependent protein deacetylase, is involved in the regulation of neuronal survival. However, the role of SIRT1 in mechanical injury is still unclear. Here, we first established a mechanical injury model of rat cortical neurons through exposing to 10 dyn/cm 2 laminar shear stress for 4 h. At the same time, we found that SIRT1 expression increased during the process of shear stress induced neuronal injury. SIRT1 overexpression in cortical neurons significantly decreased the percentage of died cells induced by shear stress. Our results demonstrate that SIRTl may play potential neuroprotective effects in shear stress induced mechanical injury.
机标关键词：
分类号：R741(神经病学)
论文发表日期：2019-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 162-167 )
英文信息