Study on Basic Biomarkers of Alzheimer's Disease with Depression

SHI Lei; LIN Duo-duo; WANG Wei-bing; WU Hai-long

摘要：Objective: To establish a rat model of Alzheimer's disease with depression, and to explore the common serum indicators that can be used to assess the occurrence of depression in Alzheimer's disease patients by routine blood testing. Methods:120 healthy male SD rats were randomly divided into healthy group, control group, dementia group and dementia with depression group, with 30 rats in each group. The rats in the three groups were tested for the basic biological markers by means of routine serum monitoring. Results: 30 rats in each healthy group and control group, 28 rats in dementia group and 27 rats in dementia with depression group completed the experiment. There were statistical differences in the levels of each biomarker in the four groups of rats (P＜0.05);there was no statistical difference in the levels of each biomarker between the healthy group and the control group ( P＞0.05);The levels of serum IL-1β, IL-6, TNF-α, CRP, and Hcy in the dementia group were higher than those in the healthy group and the control group, and the 5-HT levels were lower than those in the healthy group and the control group (P＜0.05); The levels of IL-1β, IL-6, TNF-α, CRP, and Hcy in the depression group were higher than those in the other three groups, and the levels of 5-HT were lower than those in the other three groups ( P＞0.05). Conclusion: The occurrence of depressive symptoms in Alzheimer's rats can be predicted to some extent by routine serum IL-1β, IL-6, TNF-α, CRP, Hcy and 5-HT levels, and it is inferred that the above indicators can be used as important biological markers to assess the occurrence of depression in Alzheimer's patients.