Preparation of Pectin/Chitosan-based Paclitaxel Colon-targeted Microcapsules and Study on Their Tolerance in an in vitro Artificial Gastrointestinal Tract
WEN Wei-tian
ZHANG Cai-ling
Longyan First Affiliated Hospital of Fujian Medical University,Longyan Fujian 364000,China
摘要：Objective:To develop a pectin and chitosan-based colon-targeted mi-crocapsule for paclitaxel(PTX)and evaluate its stability and drug release characteristics in an artificial simulated gastrointestinal environment.Methods:Pectin/chitosan dou-ble-polymer microcapsules(PCPM)were prepared using an ionic gelation method com-bined with spray-drying technology,with PTX as the model drug.The morphology and mechanical strength of the microcapsules were observed using a stereomicroscope,and the encapsulation efficiency and drug loading were determined.The drug release behav-ior and tolerance of the microcapsules were analyzed by simulating artificial gastric juice(pH1.2)and intestinal fluid(pH6.8)environments.Results:The average particle sizes of PPS(Note:Likely a typo in the original text;presumably a control sample such as pure pectin microcapsules)and PCPM microcapsules were(38±4)μm and(50±5)μm,respec-tively.The encapsulation efficiencies were 95.7%±1.0%and 86.2%±7.6%,and the drug loadings were 47.8%±0.5%and 43.1%±3.8%,respectively.The protection rate of PTX in PCPM microcapsules was significantly higher than that of the PTX standard in artifi-cial gastrointestinal fluid,reaching 67.0%±0.8%at 2 h.The total release rate in colonic fluid reached 91.0%±0.8%within 8 h,indicating that PCPM microcapsules achieve colon-specific drug release through enzymatic hydrolysis in the gastrointestinal tract.Conclusion:PCPM has good gastrointestinal tolerance and colon-targeted drug release performance,which is a new strategy for colon-targeted delivery of oral formulations of PTX.
机标关键词：chitosan-basedtolerancevitroastrostudygastartificialcolon-targeted
分类号：R318.08(医用一般科学)
论文发表日期：2025-03-31
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 27-33 )
英文信息