高强度聚焦超声消融普通狗扁桃体实验观察
吴显文1
李东2
王熙3
李莹3
陈文直2
胡国华1
1.重庆医科大学附属第一医院耳鼻咽喉头颈外科,重庆,4000162.重庆市生物医学工程学重点实验室，重庆市超声医学工程重点实验室-省部共建国家重点实验室培育基地，重庆 4000163.超声医疗国家工程研究中心,重庆,401121
摘要：Objective To investigate the efficacy and safety of tonsil sonication of ordinary greyhound with focused ultrasound. Material and method Desired focused ultrasound dosage combination were got from ox liver experi-ment in vitro. Bilateral tonsils of four common greyhound were sonicated with the selected dosage combination,the local and systematic symptoms and signs of the greyhound were observed after ultrasound sonication,the length and width before and after sonication were measured,and the histological change under light microscope were recorded. Results The temperatures of animals raised and then dropped to the normal level 3 days after sonication. The tonsil size become smaller to different degree after focused ultrasound sonication by a dose dependent model,with the shrinkage up to 44.5%. There is no infection,hematoma and bleeding in the local mucosal tissue. The food-intake of animal reduced 2 to 3 days after the sonication,but they did not stop eating or refused eating. Their food-intake began to recover to the primary level be-fore sonication 4 days after the sonication. It was found that there is coagulation necrosis region,hemangiectasia and hyperemia under mucosal membrane,while the surface epithelial appeared to be normal in the tonsil 3 days after the irradiation. There was granulation generated under tonsil mucosa and necrotic tissue gradually became fibrosis 7 days after sonication. Conclusion Focused ultrasound could reduce the tonsil size of the common greyhound,and obtain ablation effect by dose dependent model. There was no local bleeding infection and surrounding tissue injury during and post irradiation,and the epithelium of mucosal membrane was intact.
机标关键词：高强度聚焦超声消融扁桃体实验观察体实验
论文发表日期：2016-05-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 118-122 )
英文信息