Assessment of auditory functions in chronic hepatitis C patients treated by sofosbuvir
Elshahat Ibrahem Ismail
Ashraf Elsayed Morgan
Raghda Elsayed Farag
摘要：Objective: Evaluating the auditory function in patients with chronic hepatitis C treated with sofosbuvir and ribavirin. Methods: This study involved 80 patients with chronic hepatitis C who agreed to receive sofosbuvir and ribavirin. All participants were subjected to baseline otological and audiological assessment just before treatment. The audiological assessment included standard pure tone audiometry, extended high-frequency audiometry, immitancemetry and otoacoustic emissions (OAEs) (transient and distortion product). According to baseline hearing threshold measurements, the study population was divided into 2 groups. Group 1 included 42 patients with normal hearing sensitivity (250e8000 Hz), and Group 2 included 38 patients with sensorineural hearing loss. After 24 weeks of therapy, otological and audio-logical assessments were repeated and compared between the two groups and before and after therapy. Results: Post-treatment hearing threshold evaluation showed no significant difference from pretreat-ment evaluation at all tested frequencies. There was no statistically significant difference between pre and post-treatment otoacoustic emissions results.
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论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 10-15 )
英文信息