Cisplatin-induced vestibular hair cell lesion-less damage at high doses
Dalian Ding
Haiyan Jiang
Jianhui Zhang
Xianrong Xu
Weidong Qi
Haibo Shi
Shankai Yin
Richard Salvi
摘要：Cisplatin, a widely used anticancer drug, damages hair cells in cochlear organotypic cultures at low doses, but paradoxically causes little damage at high doses resulting in a U-shaped dose-response function. To determine if the cisplatin dose-response function for vestibular hair cells follows a similar pattern, we treated vestibular organotypic cultures with doses of cisplatin ranging from 10 to 1000 μM. Vestibular hair cell lesions progres-sively increased as the dose of cisplatin increased with maximum damage occurring around 50-100 μM, but the lesions progressively decreased at higher doses resulting in little hair cell loss at 1000 μM. The U-shaped dose-response function for cisplatin-treated vestibular hair cells in culture appears to be regulated by copper trans-porters, Ctr1, ATP7A and ATP7B, that dose-dependently regulate the uptake, sequestration and extrusion of cisplatin.
机标关键词：
资助基金：Research supported in part by a grant from NIOSH(R01OH010235)in part by NIH grant 5R01DC011808, in part by grant NIH R01DC014437, and in part by foundation of Science and Technology Commission of Shanghai Municipality(15140900900)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 115-121 )
英文信息