Chronic model of tympanic perforation in rats with mitomycin C and dexamethasone
Tomás Esteban
Noemí M.Atucha
José María Moraleda
Joaquín García-Esta(n)
Carmen L.Insausti
Javier Moraleda-Deleyto
摘要：A rat model of chronic tympanic membrane perforation was developed to be used in the search of new materials for the sealing of these perforations.A longitudinal study was carried out in rats subjected to incisional myringotomy followed by the application of mitomycin C alone or with dexamethasone.Rats were checked at days 3,7,10,14 and weekly thereafter until perforation closure,for up to 6 months.The addition of dexamethasone is a key component in order to obtain a chronic opening.Myringotomies treated with saline had a mean healing time of 8.5 days.At 8 weeks,between 62.5％ and 77.7％ of tympanic membranes treated with mitomycin C and dexamethasone remained perforated and at 6 months this number fell to 21.4％.This technique is able to maintain most tympanic membrane perforations patent for at least 8 weeks.This rat model is adequate for its use in preclinical or translational research.
机标关键词：
论文发表日期：2019-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 12-16 )
英文信息