Exposure to blast shock waves via the ear canal induces deficits in vestibular afferent function in rats
Yue Yu1
Jun Huang1
Xuehui Tang1
Jerome Allison2
David Sandlin3
Dalian Ding4
Yi Pang5
Chunming Zhang6
Tianwen Chen1
Nathan Yin1
Lan Chen1
William Mustain1
Wu Zhou7
Hong Zhu2
1.Departmant of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA2.Departmant of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA;Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, USA3.Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, USA4.Center for Hearing and Deafness, University at Buffalo, Buffalo, NY, USA5.Department of Pediatric, University of Mississippi Medical Center, Jackson, MS, USA6.Department of Otolaryngology, First Affiliated Hospital, Shanxi Medical University, Taiyuan Shanxi, 030001, China7.Departmant of Otolaryngology and Communicative Sciences, University of Mississippi Medical Center, Jackson, MS, USA;Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, USA;Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA
摘要：The ears are air-filled structures that are directly impacted during blast exposure. In addition to hearing loss and tinnitus, blast victims often complain of vertigo, dizziness and unsteady posture, suggesting that blast exposure induces damage to the vestibular end organs in the inner ear. However, the underlying mechanisms remain to be elucidated. In this report, single vestibular afferent activity and the vestibulo-ocular reflex (VOR) were investigated before and after exposure to blast shock waves (～20 PSI) delivered into the left external ear canals of anesthetized rats. Single vestibular afferent activity was recorded from the superior branch of the left vestibular nerves of the blast-treated and control rats one day after blast exposure. Blast exposure reduced the spontaneous discharge rates of the otolith and canal afferents. Blast exposure also reduced the sensitivity of irregular canal afferents to sinusoidal head rotation at 0.5-2Hz. Blast exposure, however, resulted in few changes in the VOR responses to sinusoidal head rotation and translation. To the best of our knowledge, this is the first study that reports blast exposure-induced damage to vestibular afferents in an animal model. These results provide insights that may be helpful in developing biomarkers for early diagnosis of blast-induced vestibular deficits in military and civilian populations.
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论文发表日期：2020-09-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 77-85 )
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