Missing perilymph but leaking blood-endolymph and vestibulocochlear nerve barriers in idiopathic sudden sensorineural hearing loss: A case study
Jing Zou
摘要：Objectives: To evaluate the pathological changes in the blood-perilymph, blood-endolymph, and blood-nerve barriers of a patient with idiopathic sudden sensorineural hearing loss (SSNHL).Methods: Potential ossification or fibrosis in the inner ear was evaluated using temporal bone CT and MRI acquired using the 3-dimensional T2-weighted sampling perfection with application-optimized con-trasts using a flip angle evolution sequence. Pathological changes in the barriers were analyzed by MRI obtained 4 h after a single-dose intravenous injection of gadolinium chelate using a medium inversion-time inversion recovery imaging with magnitude reconstruction sequence. Results: The perilymph was absent, while significant enhancements of the vestibulocochlear nerve and the endolymphatic compartments were detected. Conclusion: Significant injuries in the blood-endolymph and blood-vestibulocochlear nerve barriers and disabled perilymph production may contribute to the development of SSNHL with poor response to treatments.
机标关键词：
资助基金：This work was supported by the National Natural Science Foundation of China(81771006)
论文发表日期：2020-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 171-173 )
英文信息