Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome:A case control study
Theofano Tikka
Mohd Afiq Mohd Slim
Trung Ton
Anna Sheldon
Louise J.Clark
Georgios Kontorinis
Department of Ear,Nose and Throat Surgery,Queen Elizabeth University Hospital,345 Govan Rd,Glasgow,G51 4TF,United Kingdom
摘要：Objective:It remains unknown whether calcium metabolism has any effect on the clinical presentation of superior semicircular canal dehiscence(SSCD).Our aim was to analyse the adjusted calcium and vitamin D levels in SSCD patients compared to a control group.Methods:This was a prospective case-control study performed in a tertiary referral center,university teaching hospital in the UK.It included all new patients with SSCD seen in a dedicated skull base clinic over a 5-year period(2015-2019)compared to a gender and age matched control group.The main outcome of the study was adjusted calcium and Vitamin D levels between the two groups.Results:A total of 31 SSCD patients were recruited with a matched number of control patients.The mean Vitamin D level on the SSCD group was 44.8 nmoL/l(SD:20.8)compared to 47.5 nmoL/1(SD:27.4)on the control group(p = 0.702).Mean Adjusted calcium level was 2.34 mmoL/1(SD:0.7)for SSCD compared to 2.41 mmoL/l(SD:0.11)for controls(p = 0.01),being within normal limits for both the SSCD and the control group.Conclusion:Our study did not identify a link between Vitamin D levels and presence of SSCD.Normal adjusted calcium values were found in both groups.Despite that a statistically significant lower calcium level was found in the SSCD group which could indicate that suboptimal levels of calcium may affect the micro-environment of the otic capsule at the SSC region.
机标关键词：controllevelsstudycasecanalcalciumdehiscenceinvestigation
论文发表日期：2023-03-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 49-54 )
英文信息