A study of efficacy of Nigella sativa in treatment of Meniere's disease:A randomized,placebo controlled clinical trial
Masoud Motesadi Zarandi1
Zahra Rabbani2
Mahtab Rabbani Anari3
Ali Kouhi4
Mona Zeinaloo5
1.Department of Cochlear Implant and Otorhinolaryngology,Tehran University of Medical Sciences,Tehran,Iran2.Amir Alam Hospital,Tehran University of Medical Sciences,Tehran,Iran3.Otorhinolaryngology Research Center,Amir Alam Hospital,Tehran University of Medical Sciences,Tehran,Iran4.Otorhinolaryngology Research Center,Tehran University of Medical Sciences,Tehran,Iran;Department of Otorhinolaryngology and Head and Neck Surgery,Amir Alam Hospital,Tehran University of Medical Sciences,Tehran,Iran5.Department of Community Medicine,Tehran University of Medical Sciences,Tehran,Iran
摘要：Purpose:Meniere's disease(MD),first introduced by Prosper Meniere,is characterized mainly by vertigo,tinnitus,aural fullness and sensorineural hearing loss.Though the exact pathophysiology of MD is un-known,immunologic and inflammatory interactions are possible underlying mechanisms involved in MD.This study is aimed to investigate the immunomodulatory and anti-inflammatory effect of Nigella sativa on MD as a therapeutic agent.Methods:We divided 40 patients with definite MD into two groups of 20 cases.The study group received 1 g of Nigella sativa oil daily for three months and the control group received a placebo.Changes in hearing,tinnitus and vertigo were estimated by pure tone audiometry,tinnitus handicap inventory questionnaire and dizziness handicap inventory questionnaire,respectively.Results:At the end of the study we did not observe any significant improvement in study's group hearing threshold,tinnitus and vertigo compared to the control group.Conclusions:In this study,statistical analysis showed that Nigella sativa failed to improve signs and symptoms of MD.However,further investigations with a larger study population are needed to ascertain the current conclusion.
机标关键词：clinicalsativatrialstudycontrolleddiseaseefficacymeniere
论文发表日期：2023-06-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 97-100 )
英文信息