Intratympanic injection of hydrogel nanodrug for the prevention and treatment of sensorineural hearing loss
Tianying Zhai1
Pingping Ai2
Zhaohui Tang3
Chaoliang He3
Xuesi Chen3
Shiming Yang1
Nan Wu1
1.Senior Department of Otolaryngology-Head & Neck Surgery,PLA General Hospital,Beijing,China;National Clinical Research Center for Otolaryngologic Disease,Beijing,China;State Key Lab of Hearing Science,Ministry of Education,Beijing,China;Beijing Key Lab of Hearing Impairment Prevention & Treatment,Beijing,China2.Senior Department of Otolaryngology-Head & Neck Surgery,PLA General Hospital,Beijing,China;National Clinical Research Center for Otolaryngologic Disease,Beijing,China;State Key Lab of Hearing Science,Ministry of Education,Beijing,China;Beijing Key Lab of Hearing Impairment Prevention & Treatment,Beijing,China;Zhejiang Chinese Medical University,Hangzhou,China3.Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,China
摘要：Safe and efficient drug delivery to the inner ear has always been the focus of prevention and treatment of sensorineural deafness.The rapid development of nanodrug delivery systems based on hydrogel has provided a new opportunity.Among them,thermo-sensitive hydrogels promote the development of new dosage form for intratympanic injection.This smart biomaterial could transform to semisolid phase when the temperature increased.Thermo-sensitive hydrogel nanodrug delivery system is expected to achieve safe,efficient,and sustained inner ear drug administration.This article introduces the key techniques and the latest progress in this field.
机标关键词：injectionhydrogellosshearingintratympanicnanodrugpreventionsensorineural
论文发表日期：2023-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 235-239 )
英文信息