Roles of supporting cells in the maintenance and regeneration of the damaged inner ear:A literature review
Jing-Ying Guo
Jun-Yi Xu
Shu-Sheng Gong
Guo-Peng Wang
Department of Otolaryngology-Head and Neck Surgery,Beijing Friendship Hospital,Capital Medical University,Beijing,China;Clinical Center for Hearing Loss,Capital Medical University,Beijing,China
摘要：The inner ear sensory epithelium consists of two major types of cells:hair cells(HCs)and supporting cells(SCs).Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have long been elucidated.SCs are indispensable components of the sensory epithelia,and they maintain the structural integrity and ionic environment of the inner ear.Once delicate inner ear epithelia sustain injuries(for example,due to ototoxic drugs or noise exposure),SCs respond immediately to serve as repairers of the epithelium and as adapters to become HC progenitors,aiming at morphological and functional recovery of the inner ear.This regenerative process is extensive in non-mammals,but is limited in the mammalian inner ear,especially in the mature cochlea.This review aimed to discuss the important roles of SCs in the repair of the mammalian inner ear.
机标关键词：literatureregenerationmaintenancereviewcellsdamagedinnerroles
论文发表日期：2024-12-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 234-240 )