"Clinical Management of Acute Mastoiditis in a Pediatric Patient with Leukocyte Adhesion Deficiency"
Allahverdi Aghayev
Alparslan Gonul
Hazan Basak
Department of Otolaryngology,Ankara University,School of Medicine,Ankara,Turkey
摘要：Leukocyte adhesion deficiency type-1 is frequently associated with otorhinolaryngological manifestations,most notably a high prevalence of otitis media.Although multiple case reports have documented an increased prevalence of acute otitis media and mastoiditis in patients with LAD-1,no clinical or experimental studies have fully elucidated the pathophysiological mechanisms underlying this association.Despite guideline recommen-dations for urgent antibiotic therapy in immunocompromised patients with acute otitis media,a standardized treatment protocol for its complications remains lacking.Moreover,no established consensus exists regarding the optimal therapeutic approach for Leukocyte adhesion deficiency type-1 associated cases.This report contributes to the scarce literature on acute mastoiditis in LAD-1 and underscores the need for a tailored,multidisciplinary approach.In the absence of standardized treatment protocols,further research is crucial to refine management strategies and improve outcomes in immunocompromised patients with acute otitis media complications.
机标关键词：managementclinicalpatientwithacuteadhesiondeficiencyleukocyte
论文发表日期：2025-04-30
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 127-132 )
英文信息