Abstract:HUANG Yuanyu founded the theoretical doctrine of"qi circulation,the four dimensions of the earth pivot".Based on the theory of qi transformation and ascending and descending,and combined with the theory of five evolutive phases and six climatic factors,a physiological model of six qi uniting the twelve meridians is established,which categorizes the activities of the meridians and internal organs as changes of qi,and a unique theoretical system is formed by qi transformation model of"the four dimentions of the earth pivot"combined with the detailed elaboration of the mechanism of qi ascending and descending.Based on the qi transformation and ascending and descending theoretical model of HUANG Yuanyu,this study explains the characteristics of the theoretical model,and chooses stranguria as the main line to compare the differences between HUANG Yuanyu's diagnosis and treatment of stranguria and the traditional understanding and discusses the characte-ristics of paying attention to the middle jiao qi and restoring qi transformation and ascending and descending as the first priority in his medication and prescription.

Abstract:Papillary thyroid carcinoma is one of the most common malignant tumors in the endocrine system.There is no unified standard of traditional Chinese medicine(TCM)syndrome differentiation and treatment.From the perspective of sweat pore,this paper discusses the theoretical connotation of facial sweat pore and its connection with the reprogramming of glucose metabolism for the first time,further clarifies that the occurrence and development of papillary thyroid carcinoma may be related to the reprogramming of glucose metabolism induced by the glucose sweat pore stagnation.Therefore,it is proposed that the method of relieving facial sweat pore stagnation can be used clinically to inhibit the reprogramming state of tumor glucose metabolism,thereby delaying the progression of the disease,which provides a new idea for TCM diagnosis and treatment of papillary thyroid carcinoma.

Abstract:Chronic heart failure combined with intestinal dysfunction is one of the end-stage complications of patients with heart failure.The interaction between chronic heart failure and intestinal dysfunction in the occurrence and development process has attracted increasing attention from medical practitioners,but the current treatment of this disease is still limited.Based on the theory of"The heart is exteriorly and interiorly related to the small intestine",and according to the clinical manifestation and pathogenesis of the disease,the paper proposes the staged treatment strategy of invigorating qi and strengthening spleen and nourishing heart,dispelling dampness,activating collaterals and protecting the intestine in the early stage of the disease;warming yang,invigorating spleen and nourishing heart,dissipating phlegm,clearing collaterals and stabilizing the intestine in the middle stage of the disease;and tonifying kidney,invigorating spleen and nourishing heart,regulating water,clearing collaterals and streng-thening intestine in the late stage of the disease.The goal of this study is to explore the feasibility and advantages of traditional Chinese medicine in the differentiation and treatment of chronic heart failure complicated with intestinal dysfunction by combining classical theory with modern researches,so as to provide new ideas and methods for the clinical diagnosis and treatment of this disease.

Abstract:Objective:To explore the clinical efficacy of Poge Jiuxin Decoction(破格救心汤)in the treatment of acute heart failure after myocardial infarction.Method:Ninety-one patients with acute heart failure after myocardial infarction were selected and divided by using random number table method,including 42 patients in the observation group and 49 patients in the control group.The control group was treated with conventional western medicine,and the observa-tion group was treated with Poge Jiuxin Decoction orally on the basis of the treatment of the control group.The changes of resting heart rate and systolic blood pressure before and after treatment were observed.N-terminal B-type natriuretic peptide(NT-proBNP),left ventricular ejection fraction(LVEF),left ventricular end-diastolic inner diameter(LVESD),6 min walking test(6MWT)and Minnesota Living with Heart Failure Questionnaire(MLHFQ)score were compared before and after treatment.The number of hospitalizations due to cardiovascular adverse events within half a year and the occurrence of cardiovascular adverse events during the study period in the two groups were analyzed.Results:There were no significant differences in resting heart rate,systolic blood pressure,LVEF and LVESD between the two groups before and after treatment(P＞0.05).Before treatment,there was no significant difference in NT-proBNP,6MWT and MLHFQ score between the two groups(P＞0.05).After treatment,NT-proBNP and MLHFQ score in both groups were lower than those before treatment,and 6MWT was higher than that before treatment,the difference was statistically significant(P＜0.05).After treatment,NT-proBNP in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse cardiovascular events between the two groups and the number of hospitalizations due to cardio vascular adverse events within half a year(P＞0.05).Conclusion:Poge Jiuxin Decoction can improve short-term cardiac function of patients with acute heart failure after myocardial infarction,but it can not improve the long-term cardiac function.

Abstract:Objective:To explore the effect of superficial needling therapy combined with comprehensive reha-bilitation training in the treatment of aphasia after stroke of qi deficiency and blood stasis type and its effect on the neurological function of patients.Methods:A total of 80 patients with aphasia after stroke of qi deficiency and blood stasis type were selected as the study subjects,and were divided into the observation group and the control group with random number table method,with 40 cases in each group.The control group received comprehensive rehabilitation training treatment,while the observation group was supplemented with superficial needling therapy.Traditional Chinese medicine(TCM)syndrome score,Chinese Functional Communication Profile(CFCP)score,level of neural-functional defect score,clinical efficacy and incidence of adverse reactions of the two groups of patients were compared before and after treatment.Results:After treatment,the scores of speech retardation,hemiplegia and hypoesthesia in both groups were lower than those before treatment,and the scores of the observation group were lower than those of the control group,the difference was statistically significant(P＜0.05).Treatment for two months,three months(end of treatment),five months after treatment,CFCP score increased and neural-functional defect score decreased in both groups compared with those before treatment,the degree of change in the observation group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).The clinical efficacy of the observation group was better than that of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the occurrence of adverse reactions between the two groups(P＞0.05).Conclusions:Superficial needling therapy combined with comprehensive rehabilitation training can significantly improve the therapeutic effect of patients with aphasia after stroke,relieve the clinical symptoms,promote the verbal communication ability and neurological function,and its safety is guaranteed to some extent.

Abstract:Chronic kidney disease(CKD)is a common and difficult clinical disease.Professor LYU Renhe,a Traditional Chinese Medicine Master with rich clinical experience,puts forward the pathogenesis of kidney collateral miniature mass in CKD and holds that blood stasis is the key link in its formation.He also advocates the treatment of CKD by stages,namely early stage(stage of deficiency damage),middle stage(stage of deficiency strain)and late stage(stage of deficiency failure).According to the pathogenesis characteristics of kidney collateral stasis in each stage,drugs for promoting blood circulation,cooling blood and promoting collaterals,drugs for removing blood stasis and relieving water retention and dredging collaterals,drugs for removing blood stasis and searching collaterals should be applied respectively combined with the method of dispersing wind and dispelling evil,clearing heat and detoxifying,removing water and expelling turbidities,strengthening healthy qi and tonifying deficiency,which is closely related to the pathogenesis,the flexible medication reflects Master LYU's unique clinical diagnosis and treatment ideas.

Abstract:Myelosuppression is a common adverse reaction after chemotherapy for breast cancer,which has different effects on treatment and prognosis.Traditional Chinese medicine(TCM)has obvious advantages in preventing and treating myelosuppression after chemotherapy for breast cancer,but the research and prescription efficacy of myelosuppression after chemotherapy for breast cancer with different TCM syndromes are quite different.Based on this,this paper summarizes the general situation of TCM research of myelosuppression after chemotherapy for breast cancer,and focuses on the common treatment prescriptions and related mechanisms of different TCM syndromes,including heart and spleen deficiency syndrome,liver and kidney yin deficiency syndrome,qi and yin deficiency syndrome,spleen and kidney yang deficiency syndrome and yin and yang deficiency syndrome,and analyzes the pharmacological effects of TCM prescriptions on promoting the proliferation and differentiation of bone marrow hematopoietic cells,with a prospect of providing new ideas for the prevention and treatment of myelosuppression after chemotherapy for breast cancer with different TCM syndromes.There are 43 references.

Abstract:Objective:To evaluate the clinical efficacy and safety of Zizhu Ointment(紫朱软膏)in non-ischemic diabetic foot ulcer(DFU)treatment and its effect on the expression of ferroptosis-related biomarkers in patients with wound.Methods:According to the random number table method,all patients were allocated into the observation group and control group,with 53 cases in each group.On the premise of routine treatment combined with syndrome differentiation and internal treatment by Chinese medicine,Zizhu Ointment gauze dressings were applied in the observation group,while rb-bFGF combined with petroleum gauze dressings were applied in the control group.Dressings were changed once a day for 8 weeks in both group.The clinical efficacy,wound area,DMIST scale score,GSH and MDA content in wound tissue of the two groups were observed before and after treatment.Immunohistochemical changes of GPX4,SLC7A11 and TFRC in wound tissue were also compared between before and after treatment in the observation group.Adverse events were recorded during the treatment,and safety evaluation was conducted after the treatment.Results:On the clinical efficacy,wound area,DMIST scale score,GSH and MDA content in wound tissue,the observation group was superior to the control group(P＜0.05).Positive expressions of GPX4 and SLC7A11 in wound tissue were increased in the observation group while TFRC expression was decreased(P＜0.05).There was no adverse event in both groups.Conclusions:Zizhu Ointment is applicable for non-ischemic DFU in all courses.It is with good clinical efficacy and high safety,for it can reduce the wound area,improve DMIST scale score of the wound,enhance the antioxidant capacity of wound tissue,reduce the level of lipid peroxidation,and play a certain role in regulating the biomarkers related to ferroptosis in the process of wound healing.

Abstract:With the aging process of Chinese society,the prevention and treatment of perimenopausal osteoporosis have increasingly gained attention.Based on the interconnection among the heart,kidney and bone,this paper innovatively proposes the concept of the"heart-kidney-bone"axis,and the pathogenesis of perimenopausal osteoporosis is discussed from the perspective of traditional Chinese and western medicine on this basis:From the perspective of western medicine,it can be explained by neuroendocrine comorbidity;The pathogenesis of traditional Chinese medicine can be summarized as disharmony between the heart and kidney rooted in kidney deficiency.Therefore,the treatment should focus on tonifying the kidney and regulating the heart,with therapeutic principles of tonifying kidney and replenishing marrow,communi-cating the heart and the kidney.

Abstract:Objective:To investigate the effect of Bazhen Decoction(八珍汤)combined with highly active antiretroviral therapy(HAART)on the symptoms and quality of life of patients with human immunodeficiency virus infection/acquired immunodeficiency syndrome(HIV/AIDS)with deficiency of qi and blood.Methods:80 HIV/AIDS patients with deficiency of qi and blood syndrome were divided into the control group and the observation group by using random number table method,with 40 cases in each group,the observation group was treated with Bazhen Decoction combined with HAART,and the control group was treated with HAART.Symptom and sign scores,quality of life series scores,body mass index(BMI)and CD4+T lymphocyte count were compared between the two groups before and after treatment,and the safety of the treatment regimen was evaluated.Results:After treatment,the scores of symptoms and signs in both groups were lower than those before treatment(P＜0.05),and the observation group was lower than the control group(P＜0.05).After treatment,the total health perception degree,psychological field,social relation field and total score of quality of life in the observation group were increased compared with those before treatment(P＜0.05),and the social relation field and total score of quality of life in the control group were increased compared with those before treatment(P＜0.05).The total score of quality of life and the scores of overall quality of life,physiology,psychology and environment in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,BMI of the observation group was lower than that of the control group(P＜0.05).After treatment,CD4+T lymphocyte count increased in both groups(P＜0.05),and the observation group was higher than the control group(P＜0.05).Conclusion:Bazhen Decoction combined with HAART can effectively relieve the symptoms and signs of HIV/AIDS patients with qi and blood deficiency syndrome,improve the quality of life and it is of good safety.

Abstract:The article first screened out 27 kinds of bitter medicinals with the effect of promoting diuresis from Shennong's Classic of Materia Medica,analyzed their efficacy characteristics,then combined the original text of Treatise on Cold Pathogenic and Miscellaneous Diseases to analyze the compatibility and application regularities of 15 medicinals used in classical prescriptions,and finally drew the following conclusions.①In the medicinals with the effect of promoting diuresis recorded in Shennong's Classic of Materia Medica,the bitter medicinals accounted for the largest proportion.Most of them were cold in nature and have the efficacy characteristics of dissipating masses,eliminating food stagnation,removing blood stasis,and clearing heat.②The bitter medicinals with the effect of promoting diuresis in Shennong's Classic of Materia Medica were mostly used in classical prescriptions to treat various syndromes of qi counterflow caused by stagnation.When combined with pungent medicinals and bitter medicinals with other effects,they were respectively applicable to the stagnation symptoms caused by the accumulation of qi and water in the chest,abdomen and epigastrium,and water accumulation diseases gathering in the blood or accompanied by a heat syndrome.③The primary characteristic of bitter medicinals with the effect of promoting diuresis lies in their downward-directing and breaking/dispersing properties.④The herb pair of Chishao(Paeoniae Radix Rubra)-Fuling(Poria)has the effect of nourishing yin and promoting diuresis.Its application in classical prescriptions suggests that water accumulation can also cause exterior heat.⑤Zhimu(Anemarrhenae Rhizoma)in Guizhi Shaoyao Zhimu Decoction(桂知母汤)serves dual functions:"draining water"and clearing heat.

Abstract:Based on systematic traditional Chinese medicine,this article redefines the connotations and relationships of"form""qi"and"spirit",and constructs an integrated systematic theoretical model,so as to provide new ideas for the syndrome differentiation and treatment of complex diseases.Under the framework of systematic traditional Chinese medicine,a systematic analysis of"form""qi"and"spirit"is conducted:"Form"is the material basis for qi transformation and information transformation,and is the external manifestation and relatively static state of"qi"and"spirit";"Qi"is the unity of material movement and energy change,with material,functional,informational,and systemic quality characteristics,and is the driving force for the changes of"form"and"spirit";"Spirit"is the core process of information change and regulation,and is the master of"form"and"qi".The three jointly constitute the integrated framework of"matter-energy-information"for human life activities,are mutually dependent,and maintain a healthy balance.This meta-holistic view provides theoretical support for the holistic and dynamic diagnosis and treatment of diseases,offering important guidance for the syndrome differentiation and treatment of complex diseases,especially aiding in the comprehensive rehabilitation of patients with psychosomatic diseases.

Abstract:Objective:To observe the clinical efficacy of Longsha opening-closing six-qi acupuncture(here-after referred to as six-qi acupuncture)combined with Duhuo Jisheng Decoction(独活寄生汤)in treating knee osteoarthritis of the liver and kidney deficiency type.Methods:A total of 60 patients with knee osteoarthritis of the liver and kidney deficiency type were selected and divided into a control group and an observation group according to the random number table method,with 30 cases in each group.Patients in the control group were treated with oral glucosamine hydrochloride capsules,while patients in the observation group were treated with six-qi acupuncture combined with Duhuo Jisheng Decoction.Both groups underwent continuous treatment for 4 weeks.The visual analogue scale(VAS)score for pain,the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)score,the Lequesne index score,adverse reactions,and clinical efficacy were compared between the two groups.Results:After treatment,the scores of VAS,WOMAC,and Lequesne index in both groups were lower than those before treatment(P＜0.05),and the scores of the above items in the observation group were lower than those in the control group(P＜0.05).During the treatment process,1 patient in the control group presented with mild nausea and vomiting symptoms,while no obvious adverse reactions were observed in the other patients.After treatment,the total effective rate of the observation group(93.3％)was higher than that of the control group(63.3％),and the difference was statistically significant(P＜0.05).Conclusions:The combination of six-qi acupuncture and Duhuo Jisheng Decoction has a definite therapeutic effect on knee osteoarthritis of the liver and kidney deficiency type.It can significantly relieve the knee joint pain and inflammation in patients,and improve the knee joint mobility of patients with high safety.

Abstract:Parkinson's disease is a common neurodegenerative disorder of the nervous system,which is characterized primarily by the degeneration of dopaminergic neurons in the substantia nigra,leading to a reduction in dopamine neurotransmitters in the striatum and subsequent motor dysfunction.In recent years,Yinyanghuo(Epimedii Folium)has garnered widespread attention in the treatment of Parkinson's disease.This article reviews the mechanism of action of Yinyanghuo in the treatment of Parkinson's disease and elaborates on the specific mechanisms by which the main active components of icaritin and icariin,exert neuroprotective effects through antioxidation,improvement of mitochondrial dysfunction,inhibition of neuroinflammation,inhibition of neuronal cell apoptosis,and regulation of autophagy pathway,with a prospect of providing references and ideas for the clinical treatment of Parkinson's disease in the later stage.There are 46 references.inson's disease and summarizes its mechanisms of action,aiming to provide references for clinical treatment.

Abstract:The Pulse Classic by WANG Shuhe of the Western Jin Dynasty is the first to systematically categorize pulse characteristics into 24 types.This categorization has been the foundation and core of subsequent pulse inheritance and studies in traditional Chinese medicine.Among these 24 pulses,the drumskin pulse(革脉)and the soft pulse(软脉)have undergone changes during their transmission.Later transmitters often fail to understand the original reasons of the changes,leading to varying degrees of misinformation and misinterpretation:the soft pulse is replaced by the"soggy pulse"(濡脉),and the drumskin pulse becomes entangled with the"firm pulse"(牢脉).In-depth research reveals that the"drumskin pulse"and the"firm pulse"are essentially the same pulse,which should originally be the"strong pulse"(坚脉).Moreover,the soft pulse and the strong pulse are a pair of"relative pulses",differing in the force responded to the finger during palpation;the former is soft and yielding,while the latter is firm and strong.

Abstract:Evidence-based medicine is the main paradigm of contemporary medicine."Syndrome differentiation and treatment"as a distinctive feature of traditional Chinese medicine has long been regarded as the convergence point for the evidence-based transformation of traditional Chinese medicine.However,the"syndrome"in"syndrome differentiation and treatment"is not the"evidence"emphasized by evidence-based medicine.Therefore,traditional Chinese medicine should re-examine its own characteristics and explore the possibility of compatibility with evidence-based medicine under the identity of"disease-oriented".The idea of"disease-oriented"requires the traditional Chinese medicine community to undergo self-transformation in two aspects to adapt to the requirements of evidence-based medicine:one is to reconstruct the classification of traditional Chinese medicine diseases to lay the foundation for evidence-based research in traditional Chinese medicine;the other is to combine the theory of traditional Chinese medicine pathogenesis with the methodology of linguistics under the guidance of structuralist linguistics.

Abstract:"First aid stabbing of Shuigou acupoint"is a critical therapy in traditional Chinese medicine,and the mechanisms and clinical applications of this therapy in the treatment of acute encephalopathy have received significant attention.This review summarises the clinical efficacy and underlying mechanisms of the Shuigou acupoint in the treatment of acute cerebral diseases(e.g.traumatic brain injury,stroke and hepatic encephalopathy).Based on classical theories and modern research,stimulation of the Shuigou acupoint exerts therapeutic effects via multiple pathways and targets by stimulating the trigeminal nerve and other neuroanatomical structures.This includes regulating cerebral haemodynamics,inhibiting neuronal apoptosis,modulating inflammatory responses and influencing key signalling pathways.There are 43 references.

Abstract:Acupuncture is an effective method for the treatment of peripheral facial paralysis,but intractable facial paralysis is a major difficulty in acupuncture treatment.Based on the conventional acupoint selection and applying Guangming(GB37)and Hegu(LI4)source-connecting acupoints combination,the author's team can significantly relieve symptoms and enhance clinical efficacy with acupuncture in the treatment of intractable facial paralysis.Guangming acupoint can connect the liver and gallbladder,relieve depression and clear heat.Ancient literature records that it has a special therapeutic effect on eye diseases.Modern research also shows that needling the Guangming acupoint can improve blood circulation in the eyes and the neuronal activity of visual unblocking.Hegu acupoint is good at treating various diseases of the head and face.It can clear heat and improve eyesight.When combined with the Guangming acupoint,it can enhance the therapeutic effect on eye diseases.The application of Guangming and Hegu can not only effectively relieve the ocular symptoms after facial paralysis,but also promote the recovery of intractable facial paralysis by regulating the balance of yin and yang and qi and blood.

Abstract:Objective:To explore the risk factors for postoperative recurrence of colorectal adenoma with spleen deficiency and blood stasis syndrome based on Logistic regression analysis.Methods:A total of 140 patients with colorectal adenoma and spleen deficiency and blood stasis syndrome were divided into a recurrence group(68 cases)and a non-recurrence group(72 cases)according to whether there was recurrence one year after the operation.The basic information,traditional Chinese medicine(TCM)symptom and preoperative adenoma characteristics of the two groups were compared,and the risk factors for post-operative recurrence of colorectal adenoma with spleen deficiency and blood stasis syndrome were analyzed by Logistic regression model.Results:There were significant differences in age,gender distribution,number of adenomas,and the diameter of the largest adenoma between the two groups(P＜0.05).Logistic regression analysis indicated that male(OR=2.106),age≥50 years old(OR=2.090),the number of adenomas≥3(OR=2.318),and the diameter of the largest adenoma ≥10 mm(OR=2.508)were risk factors for postoperative recurrence of colorectal adenoma with spleen deficiency and blood stasis syndrome(P＜0.05).Conclusion:Postoperative male patients with colorectal adenoma and spleen deficiency and blood stasis syndrome,age ≥ 50 years old,having 3 or more than 3 adenomas,and the diameter of the largest adenoma≥10 mm,should undergo regular colonoscopy monitoring to prevent recurrence.

Abstract:Objective:To observe the clinical efficacy of acupoint application of Antai Zhixue Powder(安胎止血散)as an adjuvant therapy in the treatment of threatened abortion with kidney deficiency syndrome.Methods:A total of 100 patients with threatened abortion due to kidney deficiency were divided into an Antai Zhixue Powder acupoint application group and a placebo acupoint application group,with 50 patients in each group(1 case dropped out in the Antai Zhixue Powder acupoint application group,and 3 cases dropped out in the placebo acupoint application group).In the Antai Zhixue Powder acupoint application group,treatment was carried out using intramuscular injections of progesterone and oral admini-stration of dydrogesterone tablets combined with Antai Zhixue powder acupoint application at Shenque point(CV8)and bilateral Shenshu points(BL23).In the placebo acupoint application group,treatment was conducted using intramuscular injections of progesterone and oral administration of dydrogesterone tablets combined with specially prepared starch placebo acupoint application at Shenque point and bilateral Shenshu points.Both groups were treated continuously for 2 weeks.The hematometra area,gestational sac size,embryo size,and the levels of serum progesterone,human chorionic gonadotropin(HCG),and estradiol of the patients in both groups were observed before treatment,1 week after treatment,and 2 weeks after treatment.The clinical curative efficacy and the curative efficacy of traditional Chinese medicine(TCM)syndromes(lumbago,abdominal pain,and vaginal bleeding)in both groups were evaluated.The adverse reactions of both groups during the treatment were compared.Results:At 1 week and 2 weeks post-treatment,the gestational sac and embryo of the patients in both groups were larger than those before treatment(P＜0.05),and the levels of serum HCG and estradiol were higher than those before the treatment(P＜0.05).After 2 weeks of treatment,the hematometra area of the patients in Antai Zhixue Powder acupoint application group was smaller than that before treatment(P＜0.05),and was smaller than that in the placebo acupoint application group(P＜0.05).After treatment,the total clinical effective rate and the total effective rate of TCM syndromes in the Antai Zhixue Powder acupoint application group were higher than those in the placebo acupoint application group(P＜0.05).During the treatment period,no obvious adverse reactions were observed in either group.Conclusions:The acupoint application of Antai Zhixue Powder at the Shenque point and bilateral Shenshu points has the effect of tonifying kidney qi,preventing miscarriage,and stopping bleeding.This therapy can reduce hematometra in patients with threatened abortion due to kidney deficiency,alleviate symptoms such as lumbago,abdominal pain,and vaginal bleeding,and has no obvious influence on the hormone levels of patients.It is safer for clinical application.