Abstract:In China,body mass index over 28 kg/m2 is usually defined as obesity.Obesity is the fifth leading cause of death in the world,and its prevention and treatment effects directly affect the national health level.Recent studies have shown that metabolic adaptation is closely related to weight regain after weight loss in obese people.This article reviews the multiple difficulties and comprehensive intervention strategies in obesity management,such as metabolic adaptation,adipocyte memory effect,gene regulation,psychological factors,and environmental obesity-inducing effect,in order to provide reference for the prevention and treatment of obesity in the grassroots.

Abstract:Objective To investigate the effects of dexmedetomidine combined with sevoflurane on cerebral oxygen metabolism and immune function in patients with primary hepatocellular carcinoma(PHC)undergoing hepatectomy.Methods A total of 120 patients with PHC admitted to Inner Mongolia People's Hospital from January 2023 to December 2024 were selected as the research objects,and they were divided into control group and observation group by random number table method,with 60 cases in each group.All patients were treated with hepatectomy.The control group was treated with sevoflurane anesthesia,and the observation group was treated with dexmedetomidine combined with sevoflurane anesthesia.Heart rate,mean arterial pressure(MAP),pulse oxygen saturation(SpO2),systolic blood pressure and diastolic blood pressure were compared between the two groups before anesthesia(To),immediately after operation(T,),12 h after operation(T2)and 24 h after operation(T3).The quality of recovery,sedation and pain scores,visual analogue scale scores and blood loss were compared between the two groups.The cerebral oxygen metabolism indexes during operation and 3 d after operation,immune function indexes before operation and 3 d after operation,and the incidence of adverse reactions were compared between the two groups.Results With time,heart rate gradually decreased,MAP,systolic blood pressure and diastolic blood pressure increased first and then decreased,SpO2 decreased first and then increased in the two groups.SpO2 at T2,T3 was higher and heart rate,MAP,systolic blood pressure and diastolic blood pressure at T1,T2,T3 were lower in the observation group than in the control group(all P＜0.05).The recovery time of spontaneous breathing,the time of calling eyes opening,the visual analogue scale score,and the amount of bleeding in the observation group were significantly shorter/lower/less than those in the control group,and the Ramsay sedation score was significantly higher than that in the control group(all P＜0.05).Three days after operation,jugular venous oxygen saturation of the two groups were higher than those during operation,and arteriovenous oxygen content difference in neck(AVDO2)was lower than that during operation,and jugular venous oxygen saturation,cerebral oxygen extraction rate and AVDO2 of the observation group were lower than those of the control group(all P＜0.05).Three days after operation,the CD3+,CD4+,interleukin-6 and C-reactive protein of the two groups were lower than those before operation,and the CD3+and CD4+of the observation group were higher than those of the control group,and the interleukin-6 and C-reactive protein were lower than those of the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group[5.0％(3/60)vs 11.7％(7/60)](x2=1.098,P=0.295).Conclusion Dexmedetomidine combined with sevoflurane anesthesia in the treatment of PHC patients undergoing hepatectomy can improve the quality of recovery,reduce the impact on cerebral oxygen metabolism,and improve immune function.

Abstract:The incidence of gastric cancer is high in China(especially in western China).Although the early diagnosis of gastric cancer has been improved,the current situation is still not satisfied.MicroRNA(miR)can regulate gene expression after transcription and participate in the occurrence and development of tumors and other biological processes.As important messengers of intercellular communication,exosomes can regulate the communi-cation between local cells and distant cells by transporting specific contents(such as miR),and then affect the proliferation,invasion,metastasis and drug resistance of tumor cells.They have significant advantages over conventional diagnostic markers in clinical practice,and may become potential biomarkers for the diagnosis of gastric cancer.At present,the accuracy and effectiveness of the treatment of gastric cancer are insufficient.This article reviews the mechanism of exosomal miR in the occurrence and development of gastric cancer and its research progress as diagnostic markers and therapeutic targets of gastric cancer,in order to provide new ideas and strategies for the early diagnosis and treatment of gastric cancer.

Abstract:With the rapid development of science and technology society,artificial intelligence has been deeply involved in daily life,becoming an important achievement of modern science and technology,and one of the hottest topics in the 21st century.In the medical field,artificial intelligence has been involved in all aspects,such as disease diagnosis,drug development,patient management,and so on.Through deep learning and big data analysis,artificial intelligence can improve the safety,accuracy and efficiency of medical services.Artificial intel-ligence is widely used in clinical anesthesia,including intelligent drug delivery system,prediction of perioperative adverse events,evaluation of anesthesia depth,perioperative ultrasound,establishment of electronic data case database,intelligent teaching and so on.This allows anesthesiologists to greatly improve their work efficiency.Of course,the development of artificial intelligence still has some limitations,such as the protection of personal data privacy is not perfect,and the mechanism of artificial intelligence is complex and difficult to understand.This article will summarize the latest application progress of artificial intelligence in the field of anesthesiology and the challenges still facing.

Abstract:Sepsis is one of the diseases leading to high mortality worldwide,and microcirculation dysfunc-tion is the key pathological link in the development of sepsis to septic shock.Anisodamine hydrobromide is an alkaloid extracted from natural plants with multiple pharmacological effects of anti-inflammatory,anti-oxidative and microcirculation improvement.This article reviews the pathophysiological mechanism of microcirculation dysfunction in septic shock,discusses the protective effect and potential mechanism of anisodamine hydrobromide on microcirculation dysfunction in septic shock,and summarizes its research progress in clinical application.Studies have shown that anisodamine hydrobromide can improve microcirculation function,reduce organ damage and improve the survival rate of patients with septic shock through multi-target mechanisms,which has important clinical application prospects.

Abstract:Sepsis,as one of the most common clinical critical diseases,leads to the death of a large number of patients every year and consumes a large number of medical resources.The core of the progression of sepsis is the immune system response.In recent years,a series of new immune-inflammatory markers derived from blood routine indicators play an important role in the diagnosis,treatment and prognosis evaluation of sepsis,which are crucial for timely guidance of accurate treatment of sepsis,improvement of clinical efficacy of patients with sepsis,and early warning of organ failure.This article reviews the research progress on the correlation between new immune-inflammatory markers in blood routine and sepsis.

Abstract:Endometriosis(EMs)is a common gynecological disease in which endometrial tissue(glands and stroma)occurs outside the body of the uterus.EMs has a wide range of lesions and benign morphology,but it cannot be denied that it has clinical behavior properties similar to malignant tumors such as adhesion,invasion and metastasis,and is prone to recurrence,which seriously affects the daily life and physical and mental health of female patients.So far,the specific pathogenesis of EMs has not been completely clear,but in recent years,more and more studies have shown that intestinal flora may be closely related to the occurrence and development of EMs.The effect of intestinal flora diversity imbalance on EMs may be related to the mechanism of participating in immune response,affecting the release of inflammatory factors,and participating in estrogen metabolism.EMs can be improved by regulating intestinal flora,such as intestinal microbiota preparations,fecal microbiota transplantation,and diet regulation.This article reviews the correlation between intestinal flora and EMs,the possible pathogenic mechanism of intestinal flora on EMs,and the possible methods of treating EMs by regulating intestinal flora.

Abstract:Objective To observe the efficacy,safety and anti-inflammatory effect of Qishen granules in the treatment of heart failure with preserved ejection fraction(HFpEF).Methods A total of 80 HFpEF patients admitted to Dongzhimen Hospital,Beijing University of Chinese Medicine from December 2023 to October 2024 were selected.The patients were divided into observation group and control group by block randomization,with 40 cases in each group.All patients were given standard heart failure treatment,and the control group and the observation group were treated with placebo and Qishen granules,respectively,for 12 weeks.The decline rate of N-terminal pro-brain natriuretic peptide(NT-proBNP),New York Heart Association(NYHA)functional class,Kansas City Cardiomyopathy Questionnaire(KCCQ-12)score,traditional Chinese medicine syndrome score,6 min walk test(6MWT)distance,echocardiographic indicators,inflammatory exploratory indicators and safety evaluation were compared between the two groups.Results There were no significant differences in general data between the two groups(all P＞0.05).After 12 weeks of treatment,the levels of NT-proBNP,high-sensitivity C-reactive protein,soluble tumor suppressor 2,and tumor necrosis factor-α in the observation group were lower than those in the control group[(921±212)ng/L vs(1 054±305)ng/L,(3.2±1.3)mg/L vs(4.1±2.0)mg/L,(19±4)ng/L vs(21±4)ng/L,(34±8)mg/L vs(40±10)mg/L],and the effective decline rate of NT-proBNP,the total effective rate of cardiac function improvement,and 6MWT distance were higher/longer than those in the control group[60.0％(24/40)vs 37.5％(15/40),67.5％(27/40)vs 35.0％(14/40),(348±62)m vs(315±51)m](all P＜0.05).After 8 and 12 weeks of treatment,the KCCQ-12 scores of the observation group were higher than those of the control group,and the traditional Chinese medicine syndrome scores were lower than those of the control group(all P＜0.05).There were no significant differences in the safety indicators between the two groups(all P＞0.05).Conclusion Qishen granules can improve the rate of NT-proBNP decline in patients with HFpEF,improve cardiac function,exercise tolerance and quality of life,reduce the levels of inflammatory factors,and has good safety.

Abstract:Preeclampsia is one of the main causes of maternal mortality,and early identification,risk stratification,and targeted treatment strategies are effective measures to prevent preeclampsia and improve the clinical prognosis of patients with this condition.In recent years,with the deepening of research on vitamin D,more and more evidence has shown that sufficient and appropriate levels of vitamin D are of great significance for maintaining normal pregnancy and preventing the occurrence of preeclampsia.Vitamin D deficiency is not only associated with an increased risk of preeclampsia,but may also affect the progression and severity of the disease.However,further theoretical data is needed to support the study of its pathogenesis.Therefore,in-depth explora-tion of the mechanism of vitamin D in preeclampsia not only helps us better understand the pathogenesis of preeclampsia,but also provides ideas for developing new prevention and treatment strategies.

Abstract:Objective To investigate the clinical effect and safety of Mongolian medicine Sandthorn Wuwei powder combined with conventional treatment on patients with hypoxic pulmonary hypertension(HPH).Methods A total of 89 patients with HPH admitted to the Department of Cardiovascular Medicine,Inner Mongolia Autonomous Region People's Hospital from August 2022 to August 2024 were retrospectively analyzed.According to the treatment method,the patients were divided into the control group(44 cases)and the observation group(45 cases).The control group received conventional treatment such as oxygen therapy,diuretics,and calcium channel blockers,and the observation group was treated with Sandthorn Wuwei powder on the basis of the control group.Both groups were treated for 6 months.The exercise endurance,cardiopulmonary function,blood gas indexes,inflammatory factors,oxidative stress markers,imaging,vascular endothelial function,and quality of life were compared between the two groups before and after treatment.The clinical efficacy was compared between the two groups.Results After treatment,6 min walking distance,forced expiratory volume in one second,forced expiratory volume in one second/forced vital capacity,peak expiratory flow,arterial oxygen partial pressure,superoxide dismutase,nitric oxide metabolites,and right ventricular ejection fraction levels in the observation group were significantly longer/higher than those in the control group;Borg score,pulmonary artery systolic pressure,arterial partial pressure of carbon dioxide,hemoglobin,interleukin-6,tumor necrosis factor α,8-isoprostan-F2α,malondialdehyde,right ventricular end diastolic volume,endothelin-1,pulmonary hypertension specific scale score,and Mongolian medicine syndrome score were significantly lower than those in the control group(all P＜0.05).The total effective rate of the observation group was significantly higher than that of the control group[80.0％(36/45)vs 61.4％(27/44)](P=0.008).Conclusion Sandthorn Wuwei powder combined with conventional treatment can significantly improve pulmonary hemodynamics,exercise endurance and quality of life in patients with HPH,and its mechanism may be achieved by anti-inflammation,anti-oxidation,regulation of vascular endothelial function and inhibition of pulmonary vascular remodeling,with good safety.

Abstract:Objective To investigate the clinical effect of Linaoxin capsule combined with tirofiban in the treatment of acute myocardial infarction.Methods A total of 118 patients with acute myocardial infarction admitted to the Affiliated Hospital of Qingdao University from September 2023 to September 2024 were selected.They were divided into the observation group and the control group by envelope lottery method,with 59 cases in each group.The control group was treated with tirofiban,and the observation group was treated with Linaoxin capsule on the basis of the control group.The effects of the two groups were evaluated after 7 d of treatment.The clinical efficacy,cardiac function,myocardial injury markers,oxidative stress,vascular endothelial function and adverse reactions of the two groups were evaluated.Results The total effective rate of the observation group was higher than that of the control group[91.5％(54/59)vs 76.3％(45/59)](P＜0.05).After treatment,the cardiac function indexes of left ventricular ejection fraction,stroke volume,cardiac output,and cardiac index in the observation group were higher than those in the control group,and the levels of serum creatine kinase isoenzyme,cardiac troponin Ⅰ,and myoglobin in the observation group were lower than those in the control group(all P＜0.05).After treatment,the levels of serum malondialdehyde and myeloperoxidase in the observation group were lower than those in the control group,and the level of superoxide dismutase was higher than that in the control group(all P＜0.05).After treatment,the vascular endothelial function indexes of nitric oxide,vascular endothelial growth factor and vascular endothelin-1 in the observation group were better than those in the control group(all P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The clinical effect of Linaoxin capsule combined with tirofiban in the treatment of acute myocardial infarction is significant,which can improve the cardiac function of patients,reduce the level of myocardial injury markers,inhibit the body's oxidative stress response,improve the vascular endothelial function of patients,and the treatment safety is good.

Abstract:Uterine diverticulum is a rare uterine malformation,which is rarely reported in domestic and foreign literature.Its clinical manifestations lack specificity and can easily lead to misdiagnosis or missed diagnosis.This article explores the diagnostic strategy and individualized treatment mode of this disease through a typical case.The patient,a 32 year old female,presented with the main complaint of"prolonged menstrual period for more than 2 years and vaginal bleeding for 2 months".Transvaginal four-dimensional ultrasound and pelvic magnetic resonance imaging suggest a depression on the anterior wall of the cervix,which is further confirmed by hysteroscopy as cervical diverticulum.The patient underwent cervical diverticulectomy under laparoscopy,during which the diverticulum was completely removed and the cervical muscle layer defect was repaired.After a 6-month follow-up,the patient's menstrual cycle returned to normal.Congenital cervical diverticulum is a rare disease with non-specific clinical symptoms that require differential diagnosis through multimodal imaging combined with hyste-roscopy.Congenital cervical diverticulum is commonly characterized by abnormal uterine bleeding and infertility,which can be easily confused with other gynecological diseases.It is recommended to combine imaging and endoscopic examination to achieve accurate diagnosis,and choose personalized surgical plans based on the patient's reproductive needs.This case provides important reference for clinical treatment of such rare diseases.

Abstract:Indoxyl sulfate is a gut-derived protein binding uremic toxin.With the progressive reduction of renal filtration function in patients with chronic kidney disease(CKD),indoxyl sulfate accumulates in the body,which further aggravates the progress of CKD.This review discusses the effects of indoxyl sulfate on CKD,and discusses the effects of indoxyl sulfate on renal tubular epithelial cells in CKD patients from the aspects of oxidative stress,inflammatory response,and mitochondrial dysfunction,so as to provide ideas for protecting residual renal function in dialysis patients and delaying disease progression.

Abstract:Objective To analyze the related factors of substandard concentration of cefoperazone sulbactam(SCF)in patients with ventilator-associated pneumonia(VAP)and to evaluate the dosing regimen of SCF in the treatment of VAP by Monte Carlo simulation(MCS).Methods A total of 172 VAP patients admitted to Renji Hospital,Shanghai Jiao Tong University School of Medicine from April to September 2021 were selected as the research objects.According to the steady-state trough concentration of SCF in VAP patients,the patients were divided into substandard group(64 cases)and standard group(108 cases),and the related factors of substandard SCF concentration in VAP patients were analyzed.MCS was used to analyze the compliance of each regimen at different infusion times.Results Multivariate Logistic regression analysis showed that age,craniocerebral injury,creatinine clearance rate(CCr)level and continuous renal replacement therapy(CRRT)were independent influencing factors for substandard SCF plasma concentration in VAP patients(all P＜0.05).The area under the curve of Logistic regression model for predicting substandard SCF plasma concentration in VAP patients before and after internal verification was 0.873(95％confidence interval:0.839-0.898)and 0.875(95％confidence interval:0.844-0.901),respectively,which had a good prediction efficiency.The results of MCS analysis showed that with the increase of drug infusion time,the target achievement probability(PTA)showed an upward trend under different administration regimens and infusion time.However,each dosing regimen had a specific minimum inhibitory concentration(MIC)threshold.When the pathogen MIC was below this threshold,the infusion time could be adjusted to achieve the desired pharmacodynamic goal of PTA＞90％.When the pathogen MIC was ≤16 μg/ml,PTA＞90％could be achieved by optimizing the dosing regimen and prolonging the infusion time.However,when the pathogen MIC was ≥ 32 μg/ml,the therapeutic goal of PTA＞90％could not be achieved regardless of the dosing regimen or infusion time.For empirical treatment,the cumulative response rate reached more than 90％when only 3 g(q6 h)regimen was infused for 4 h.Conclusion The age,CRRT,craniocerebral injury and CCr level should be fully considered when selecting SCF dosing regimen for VAP patients.The pharmacokinetic/pharmacodynamic synergism induced by SCF infusion dosing regimen shows a selective characteristic for MIC.For the pathogens at the upper or borderline high sensitivity threshold,the administration strategy can be optimized,including adjusting the administration interval,increasing the drug dose,and prolonging the infusion time,so as to achieve the maintenance of effective blood drug concentration.

Abstract:Objective To investigate the differences of intraoperative related indicators,clinical efficacy,safety,postoperative quality of life and patient satisfaction between low-dose(0.2-＜0.5 ml)and standard-dose(0.5-1.5 ml)lauromacrogol sclerotherapy in the treatment of hemorrhagic internal hemorrhoids,in order to provide scientific basis and reference for clinical practice.Methods A total of 137 patients with hemorrhagic internal hemorrhoids who received lauromacrogol sclerotherapy in Xiangyang Central Hospital,Hubei Province from January 2021 to November 2024 were selected.According to the single injection dose,they were divided into standard-dose group(99 cases)and low-dose group(38 cases).The intraoperative indicators,postoperative complications,clinical efficacy,quality of life and patient satisfaction were compared between the two groups.Results The operation time,average dose of single injection point and total injection volume in the low-dose group were shorter/less than those in the standard-dose group[(23±3)min vs(25±4)min,(0.46±0.08)ml vs(0.95±0.33)ml,(1.8±0.6)ml vs(4.4±1.9)ml](all P＜0.05).The incidences of postoperative dirt and anal distension in the low-dose group were significantly lower than those in the standard-dose group(both P＜0.05).At least 8 weeks of follow-up,the incidences of bleeding and prolapse in the standard-dose group were higher than those in the low-dose group(both P＜0.05).There was no significant difference in the total effective rate between the standard-dose group and the low-dose group[99.0％(98/99)vs 100.0％(38/38)](P=0.303).The low-dose group performed better than the standard-dose group in mobility,self-care ability,and daily activities(all P＜0.05).Patients in the low-dose group were more satisfied than those in the standard-dose group(P=0.02).Conclusion For patients with hemorrhagic internal hemorrhoids,endoscopic single-point injection of low-dose and standard-dose lauromacrogol has the same effect,and has fewer postoperative complications,better quality of life,and higher patient satisfaction.

Abstract:Traumatic brain injury is a common nervous system injury,and its healing and repair are affected by many factors.The differentiation and maturation process of endogenous neural stem cells(eNSCs)after traumatic brain injury is of great significance for the rehabilitation of the nervous system.The local hypoxia,inflammation and cell death after traumatic brain injury can promote the activation and differentiation of eNSCs through multiple signaling pathways.Cytokines,microRNA,neuron-derived extracellular vesicles,and mitochondrial biosynthesis can be used as regulatory factors to make eNSCs differentiate into neurons and glial cells under specific conditions,and create a good microenvironment for nerve repair by regulating inflammatory response.The combination of tissue engineering technology and eNSCs can further effectively promote nerve regeneration and functional recovery.This article reviews the research progress of eNSCs differentiation and maturation in traumatic brain injury,focusing on its potential therapeutic mechanism and clinical application prospects,in order to provide reference and enlighten-ment for future research.

Abstract:Objective To observe the pathological types and distribution of abnormal uterine bleeding in postmenopausal women,analyze the relationship between different pathological types and clinical characteristics,and explore the risk factors of endometrial malignant and precancerous lesions in postmenopausal women with abnormal uterine bleeding.Methods The clinical data of 894 patients with postmenopausal abnormal uterine bleeding who underwent hysteroscopy and endometrial localization biopsy in Beijing Obstetrics and Gynecology Hospital,Capital Medical University from May 1,2018 to May 1,2023 were retrospectively analyzed.The pathological and clinical characteristics of the patients were summarized.Multivariate Logistic regression was used to analyze the risk factors of endometrial malignant and precancerous lesions in postmenopausal women with abnormal uterine bleeding.Results Among 894 patients with abnormal uterine bleeding after menopause,the pathological types were mainly benign lesions,accounting for 710 cases(79.4％),of which endometrial polyps accounted for the largest proportion,269 cases(30.1％),malignant and precancerous lesions accounted for 184 cases(20.6％),and endometrial cancer was the most common,accounting for 151 cases(16.9％).There were significant differences between the two groups in age,menopausal years,fertility,diabetes mellitus,endometrial echo uniformity,endometrial thickness ≥0.5 cm,duration of abnormal uterine bleeding,normal coagulation function and normal proportion of tumor markers(all P＜0.05).Multivariate Logistic regression analysis showed that long menopausal years(6-10 years,＞10 years),non-childbearing,endometrial thickness ≥0.5 cm,abnormal tumor markers were the risk factors for endometrial malignant and precancerous lesions in postmenopausal patients(all P＜0.05).Conclusion The main cause of abnormal uterine bleeding after menopause is benign lesions,and the occurrence of malignant and precancerous lesions is related to the years of menopause,fertility,endometrial thickness and tumor markers.

Abstract:Heart failure,as one of the most common chronic diseases in the elderly population,not only affects the physical health of patients,but also affects the quality of life of patients with a variety of complications,especially cognitive dysfunction.In recent years,the management of blood pressure in patients with heart failure has received increasing attention.Related studies have shown that there is a close correlation between blood pressure level and cognitive dysfunction.Hypertension,hypotension and blood pressure variability may have different degrees of impact on cognitive function,but the mechanism of these effects has not been fully elucidated.In addition,the effectiveness and adaptability of clinical interventions need to be further explored.This article aims to review the current status of blood pressure management in patients with heart failure,analyze its effects on cognitive function and potential physiological mechanisms,explore the existing problems in current research,and propose future research directions,in order to provide new ideas for improving the overall health of patients with heart failure.

Abstract:As an important supplement to commercially available drugs,medical institution preparations have a wide range of needs in clinical application.Among them,traditional Chinese medicine granules have become an important part of preparations in medical institutions because of their advantages of rapid absorption and convenient administration.However,with the rapid development of medical technology,there are still obvious deficiencies in the intelligence and standardization of existing traditional Chinese medicine equipment.As a result,traditional Chinese medicine preparations in medical institutions are generally faced with problems such as backward preparation process,unstable equipment performance,and poor quality uniformity,which restrict the clinical efficacy.This article systematically analyzes the research progress of clinical application and preparation process of traditional Chinese medicine granules in recent years,and deeply discusses its development status,key issues and future trends,in order to provide theoretical basis and practical guidance for the process improvement,innovation and development of preparations in medical institutions.

Abstract:Xiaochaihu decoction,which is contained in Zhang Zhongjing's Treatise on Typhoid Fever of the Eastern Han Dynasty in China,consists of Chaihu,Scutellaria baicalensis,Pinellia ternata,Radix et Rhizoma Ginseng,Radix et Rhizoma Glycyrrhizae,Ginger and Jujubae,and its main effects are to reconcile Shao-Yang,harmonise the stomach and lower the rebelliousness,and support the positive and dispel the evil spirits.In clinical studies,it is mostly used in the treatment of chronic gastritis,gastroesophageal reflux disease,peptic ulcer,irritable bowel syndrome,chronic hepatitis B,digestive tract tumors and other digestive system diseases.Modern pharmacology shows that Xiaochaihu decoction has anti-inflammatory,anti-oxidation,mucosal barrier protection,antibacterial,immune regulation,anti-tumor and other pharmacological effects in the treatment of digestive diseases.This article summarizes the clinical research on the digestive system,the pharmacological components of each component of the formula in the treatment of digestive system diseases,and the animal experimental research of Xiaochaihu decoction,and discusses the compatibility of its pharmacological components,so as to provide reference for further research.