Abstract:Objective:To evaluate the effect of Jingwanhong ointment(京万红软膏)on healing of chronic wounds of leg of diabetic patients,to compared with routine treatment by multicenter completely randomized,parallel comparison.Methods:A total of 1 1 hospitals participated in this study,and multicenter,randomized,parallel com-parison was used to compared with routine treatment. One hundred and thirty-one patients with diabetic foot ul-cers were randomly divided into Jingwanhong ointment group (67 patients)and compound sulfadiazine zinc cream group (64 cases),and mean wound area was (16.7±6.1)cm2 and (15.9±8.3)cm2 ,respectively. Duration of ul-ceration was (45.7±68.3)days and (52.5±79.6)days,respectively. Patients of the two groups received Jing-wanhong ointment or compound sulfadiazine zinc cream respectively for a duration of 20 weeks.Results:There was no statistically significant difference in patients’age,duration of suffering from diabetes,routine blood tests,liver function,renal function,etc. In 2,5,10,15 weeks,wound healing rates of Jingwanhong group were higher than that of compound sulfadiazine zinc cream group,especially at 5 and 10 weeks (P<0.01). The average duration ofepithelization of wounds was (46.5±15.6)days in the Jingwanhong group and (67.9±17.9)days in the com-pound sulfadiazine zinc cream group,respectively,with statistically significant difference (P<0.05).Conclusions:Both Jingwanhong ointment and compound sulfadiazine zinc cream could promote healing of diabetic foot wound, and the effect of Jingwanhong ointment is superior.

Abstract:Objective:To observe the clinical effect of vacuum-assisted closure treatment combined with flushing with epidermal growth factor solution in treating deep Ⅱ degree burn wound.Methods:Sixty patients with 5%-10% TBSA,deep Ⅱ degree burn wound on extremities,aging from 18 to 60 years old,were randomly divided in-to treatment group and control group. Patients received vacuum-assisted closure treatment,and epidermal growth factor solution (treatment group)or normal saline (control group)was used to flush the wounds,with the vacu-um-assisted closure device operated 2 times per day. The device was renewed on the 5th,10th,15th day,while the wound healing rate and wound healing time were observed.Results:Fever was observed in 1 1 (3 6.6%,)and 1 2 (40.0%)patients in the treatment group and control group respectively,and the difference was not significant(χ2= 0.071,P=0.791). The wound healing rates on the 10th and 15th day respectively in the treatment group [0.476 70±0.027 83 and 0.780 70±0.025 99]were significantly higher than those of the control group [0.425 70±0.024 45 and 0.731 30±0.029 45;P<0.05],and the wound healing time in the treatment group was (19.27±1.82)days,and (23.10±2.07)days in the control group (P<0.05). Before treatment,bacterial cul-ture of wound exudate was positive in 5 wounds of treatment and 6 wounds in control groups. Wounds in two pa-tients were not healed in both groups,but bacterial culture was negative.Conclusions:The vacuum-assisted closure treatment combined with flushing with epidermal growth factor solution can promote wound healing,improve the effect of vacuum-assisted closure treatment alone for deep Ⅱ degree burn wounds.