Abstract:Systematic sphygmology for pattern differentiation is of great significance in the clinical diagnosis and treatment of traditional Chinese medicine(TCM).As the core method of TCM diagnosis,pulse diagnosis can reveal the etiology,pathogenesis and prognosis of diseases by analyzing the characteristics of pulses,and provide a basis for formulating precise therapeutic principles,treatment methods and prescriptions.There is an intrinsic compatibility between pulse diagnosis and traditional Chinese medicine.In clinical practice,the goal of"the syndrome emerges from the pulse and the medication is based on the syndrome"can be achieved.Through the objective analysis and reasoning of systematic sphygmology for pattern differentiation,we can not only select the appropriate prescription and drugs,adjust the drug flavors,dosage and com-patibility relationship,but also establish a new model of"pulse-herbs correspondence",so as to promote the precision and personalization of clinical diagnosis and treatment of TCM.Therefore,after the discussion and review of relevant experts from multiple fields,the clinical application specification of"pulse-herbs correspondence"of systematic sphygmology for pattern differentiation is finally constructed,which is conducive to the standardization and standardized application of the concept of"pulse-herbs correspondence"in clinical practice.

Abstract:Objective:To explore the clinical efficacy of ultrasound-guided needle knife combined with platelet rich plasma(PRP)injection in the treatment of lateral epicondylitis of the humerus.Methods:Eighty patients with lateral epicondylitis of the humerus were selected and divided into an observa-tion group and a control group by using the random number table method,with 40 cases in each group.The control group was treated with ultrasound-guided needle knife and local block therapy while the observation group was treated with ultrasound-guided needle knife combined with PRP injection.The visual analogue scale(VAS)score,modified Hospital for Special Surgery(HSS)score,Mayo elbow performance score(MEPS),the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin(IL)-1β,IL-6]and the shear wave velocity(maximum,minimum,and average)of the common tendon of the inferior extensor muscle under ultrasound of the two groups were compared.The clinical efficacy of the two groups was evaluated.Results:After treatment,the VAS scores of both groups were lower than those before treatment,and the scores of the observation group were lower than those of the control group(P＜0.05).The modified HSS scores and MEPS were higher than those before treatment,and the scores of the observation group were higher than those of the control group(P＜0.05).After treatment,the levels of TNF-α,IL-1β and IL-6 in both groups decreased,and those in the observation group were lower than those in the control group(P＜0.05).After treatment,the shear wave velocity of the total extensor tendon in both groups increased,and that in the observation group was higher than that in the control group(P＜0.05).After treatment,the total effective rate of the observation group was 90％,which was higher than 65％of the control group(P＜0.05).Conclusion:Ultrasound-guided needle knife combined with PRP injection can improve the clinical efficacy of patients with lateral epicondylitis of the humerus,relieve elbow joint pain,and facilitate the functional recovery of the elbow joint.

Abstract:This paper summarizes the clinical experience of Chief Physician WANG Jun in treating migraines with acupuncture.Migraine is a disease name in Western medicine.According to Western medical diagnosis,Master WANG classifies all symptoms into two categories:the main symptoms and the concurrent symptoms.He also conducts a traditional Chinese medicine(TCM)location analysis based on the different characteristics of the main symptoms and the concurrent symptoms,and believes that the TCM location of migraine mainly lies in the head,involving the three yang meridians of the head,the eyes,ears,tongue and other official orifices,as well as the liver,heart,spleen,stomach and kidneys and other internal organs.Based on the TCM locations and symptom characteristics of migraine,the following acupoint selection principles were established for acupuncture treatment:(1)For the main symptoms,selection is primarily based on meridian differentiation,which is combined with proximal acupoints selection;(2)For concurrent symptoms,the selection is primarily based on the differentiation of zang-fu organs.(3)For combined treat-ment of main and concurrent symptoms,selection is primarily based on root and node differentiation.Besides conventional acupuncture techniques,Master WANG emphasizes supplementary acupuncture maneuvers and patient education and care to ensure the maximum benefit from the treatment.

Abstract:Objective:To explore the effect of Yangxin Decoction(养心汤)combined with metoprolol on N-terminal B-type natriuretic peptide(NT-proBNP),heart rate variability and efficacy in patients with ventricular arrhythmia.Methods:Eighty patients with ventricular arrhythmia were randomly divided into control group and research group,40 patients in each group.The control group was treated with oral administration of metoprolol,and the research group was further treated with oral administration of Yangxin Decoction.Both groups were treated for 3 months.The total clinical effective rate and adverse reactions of the two groups after treatment were recorded.The traditional Chinese medicine(TCM)syndrome scores,the levels of serum high-sensitivity C-reactive protein(hs-CRP),NT-proBNP and adiponectin(APN)were detected before and after treatment.The standard deviation of all sinus beats(SDNN),standard deviation of mean sinus beats(SDANN),and the percentage of successive normal cardiac interbeat intervals greater than 50 msec(pNN50)were recorded by 24-hr continuous dynamic electrocardiogram recorder.Results:The total effective rate of the research group(75.00％)was higher than that of the control group(52.50％)(P＜0.05).After the treatment,in both groups the TCM syndrome scores,hs-CRP and NT-proBNP levels decreased,APN,SDNN,SDANN and pNN50 increased(P＜0.05).There was no statistically significance in adverse reactions between the two groups of patients.Conclusion:Yangxin Decoction combined with metoprolol can effectively reduce NT-ProBNP in serum of patients with ventricular arrhythmia with improved efficacy.

Abstract:Objective:To analyze the effects of Shujin Huoxue Qutong Ointment(舒筋活血祛痛膏)on pain degree and rehabilitation of lumbodorsal function in patients with thoracolumbar vertebral compression fractures after percutaneous vertebroplasty(PVP).Methods:A total of 168 patients with thoracolumbar vertebral compression fractures undergoing PVP in The Third Department of Spinal Surgery,Luoyang Orthopedic-Traumatological Hospital of Henan Province were enrolled from August 2022 to August 2024.Random number table method was applied.Patients were divided into observation group and control group,84 patients in each group.The control group was treated with routine western medicines(calcium carbonate D3 tablets+alendronate sodium tablets),while treatment group was treated with Shujin Huoxue Qutong Ointment besides treatment in the control group.Both groups were treated for 3 courses.The clinical efficacy after treatment,scores of visual analogue scale(VAS),Oswestry Disability Index(ODI)and Japanese Orthopaedic Association(JOA),levels of serum interleukin(IL)-6 and tumor necrosis factor-α(TNF-α)1 day,1 month and 3 months after surgery were compared between the two groups.The occurrence of complications in the two groups was observed.Results:The total effectiveness rate of treatment group was significantly higher than that of control group(P＜0.05).One month and 3 months after surgery,VAS scores in the observation group were significantly lower than those in control group(all P＜0.05).One month and 3 months after surgery,ODI scores in the observation group were lower than those in control group,and JOA scores were higher than those in control group(all P＜0.05).One month and 3 months after surgery,levels of IL-6 and TNF-α in the observation group were lower than those in control group(all P＜0.05).There was no significant difference in the incidence of complications between the two groups(P＞0.05).Conclusion:Shujin Huoxue Qutong Ointment is good on the effectiveness rate in thoracolumbar vertebral compression fractures after PVP.It can significantly alleviate postoperative pain,promote the recovery of thoracolumbar function and relieve inflammatory response,with certain safety.

Abstract:Based on the humanistic features and environmental characteristics of the cold regions in northern border areas,Professor ZHANG Jinliang holds that the disease cause and disease mechanism of coronary heart disease in the cold regions of northern border areas are external attack of cold and dryness,internal injury of phlegm and heat,and unsmooth blood and qi circulation.The treatment should be warming yang and dissipating cold,dispelling wind and unblocking collaterals,regulating qi and relieving depression,soothing liver and unblocking meridians;eliminating phlegm and removing blood stasis,promoting blood circulation and unblocking collaterals.In clinical practice,he proposes the thought of"eliminating origins,clearing current and rebalancing",and invents the Qingliu Pingfu Decoction(清流平复汤),with remarkable effects.This paper explores the characteristics of cold regions,analyzes the features of disease causes and mechanism in Professor ZHANG's syndrome differentiation and treatment of coronary heart disease in cold regions based on this thought.Some verified cases are provided for reference.

Abstract:The etiology of polymyositis/dermatomyositis combined with interstitial lung disease has not been clarified.Combined with the relevant traditional Chinese medicine(TCM)classics,it is believed that its clinical manifestations can be related to the lung and spleen in the five viscera of TCM.The theory of"origin-analogue"plays an important role in TCM.This paper expounds the"origin-analogue"relationship between lung and spleen from the aspects of zang-fu function,meridians and five elements.Based on the theory of"origin-analogue",the etiology and pathogenesis of the disease are explored from the two aspects of exogenous pathogen invasion and lung and spleen injury,and corresponding treatment methods are proposed in different stages(acute attack stage and remission stage),providing theoretical support for the TCM treatment of polymyositis/dermatomyositis combined with interstitial lung disease,and providing new ideas for the clinical treatment of the disease.

Abstract:Traditional Chinese medicine(TCM)system theory is a modern theory based on the cross-disciplinary research of TCM and system science,which is used to solve the increasingly complex problems related to multi-system,multi-factor,and multi-pathogenesis in modern clinical practice.This article syste-matically expounds the organic and functional principles of TCM system theory,pointing out that the organic principle emphasizes the interaction and overall correlation between various elements inside and outside the human body system,while the functional principle reveals the dynamic process of diseases from functional disorders to structural changes.This article takes oculomotor nerve palsy of"qi and blood deficiency"type as an example,combines the method of systematic sphygmology for pattern differentiation and analyzes the process flow of the patient from qi and blood depletion to loss of meridian nourishment and ultimately leading to abnormal ocular function.It explores the pathogenesis of abnormal function of A-structural abnormality-abnormal function of B,and emphasizes the core of overall tonification of qi and blood and regulation of function A in the treatment in combination with therapeutic methods such as strengthening the spleen and eliminating dampness,warming the meridians and unblocking the collaterals,it achieves functional repair from the overall to the local level.It aims to demonstrate the advantages of TCM systems theory in analyzing the mechanisms of complex diseases and guiding systematic treatment,providing theoretical and clinical references for modern TCM in dealing with complex diseases involving multiple systems and factors.

Abstract:Objective:To study the effect of tongue acupuncture therapy combined with ultrasound on swallowing function of patients with dysphagia after radiotherapy for nasopharyngeal carcinoma.Methods:Sixty patients with dysphagia after radiotherapy for nasopharyngeal carcinoma who visited Cangzhou Integrated Traditional Chinese and Western Medicine Hospital from January 2022 to May 2023 were selected and randomly divided into the control group(conventional rehabilitation and ultrasound treatment)and the observation group(conventional rehabilitation,ultrasound therapy,and tongue acupuncture therapy)according to the order of treatment,with 30 cases in each group.The duration of the swallowing period before and after treatment in the two groups of patients was determined by television fluorescence swallowing study(VFSS).The water swallowing test(WST)grades of the two groups of patients before and after treatment were evaluated by using the WST test.The clinical efficacy was valuated based on the changes in WST grades.The swallowing function of the two groups of patients before and after treatment was evaluated by using the Chinese version of the Anderson Dysphagia Scale(MDADI).Results:After treatment,the durations of the oral phase,swallowing reflex,pharyngeal phase,laryngeal closure phase in both groups decreased.Moreover,the observation group were greater than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the WST grades of the two groups of patients were better than those before treatment,and the observation group after treatment were better than those of the control group.The clinical efficacy of the observation group after treatment was better than the control group.MDADI score in both groups decreased,the observation group was greater than those in the control group.Conclusions:Tongue acupuncture therapy combined with ultrasound treatment can reduce the time required for swallowing food ball,liquids,and coughing during swallowing in patients with dysphagia after radiotherapy for nasopharyngeal carcinoma,as well as improve the swallowing function and enhance the quality of life.

Abstract:This article introduces Professor WANG Wenjian's"three-in-one"academic thought on paste prescriptions,which revolves around the three modules of"disease,symptom,and constitution",and achieves precise identification,tailored treatment,and flexible medication through the combination of disease diagnosis,symptom diagnosis,and constitution diagnosis.The guiding principle of the"three-in-one"is"conditioning in winter and curing diseases as the first priority",aiming to emphasize that the original intention,nature,and purpose of traditional Chinese medicine paste prescriptions are for treating diseases and promoting health,rather than just for nourishing the body.The first layer of the"three-in-one"is based on disease differentiation,and the same disease is treated with similar way;the second layer involves modifying based on symptom differentiation and balancing the body and spirit;the third layer is adjusting treatment based on the body constitution differentiation,making appropriate treatment individualized to patient,season and locality.One test case is attached.

Abstract:Ulcerative colitis is a chronic non-specific intestinal disease characterized by inflammatory changes in the mucosa of the colon and rectum.Toxicity and turbidity run through the entire course of the disease.The theory of"turbid-toxin lurking in the collaterals"proposed by renowned traditional Chinese medicine Master LI Diangui is of great significance in explaining the dynamic evolution process of this disease.The intestinal collaterals are intricately interwoven,capable of circulating qi and blood,and nourishing and irrigating the intestines.The latent toxins and pathogenic factors have characteristics such as lurking in the abyss,being sticky and difficult to dissolve,remaining dormant and recurring,and gradually accumulating in the collaterals.Therefore,during the active stage of ulcerative colitis,it is triggered by external factors,with latent toxins moving internally,toxicity lurking in the collaterals,and damage to the collaterals and tissues;in the remission stage,the pathogenesis is characterized by long-term illness causing damage to the collaterals,latent toxins remaining internally,turbid-toxin hidden in the collaterals,and intestinal weakness with blood stasis in the collaterals.In clinical treatment,the"eliminating the stagnated pathogen"method is used for differentiation and treatment based on the syndrome.During the active stage,pungent herbs are used to unblock the collaterals,eliminate turbidity and disperse toxins,remove stagnant matter and expel pathogenic factors;in the remission stage,sweet herbs are used to nourish the meridians,harmonize turbidity and alleviate toxins,and strengthen the collaterals and eliminate stagnated pathogen.

Abstract:Chronic atrophic gastritis with intestinal metaplasia is a chronic and intractable digestive disease,which is clinically characterised by weakness of the spleen and stomach,deficient earth being subjugated by wood,and emotional anxiety.The pathogenesis is characterized by dysfunction of the vital energy mechanism,the liver's failure of governing conveyance and dispersion,and weakness of the spleen and stomach.Therefore,based on the Shan's method of soothing the liver and regulating spirit,a new acupuncture treatment method of"strengthening the spleen,soothing the liver and regulating the spirit"is created,which combines acupuncture and moxi-bustion.This method follows the principle of tonifying deficiency and eliminating excess,and harmonizing yin and yang.It selects acupoints such as Baihui(DU20),Yintang(EX-HN3),Shenting(DU24),Neiguan(PC6),Taichong(LR3),Zhongwan(RN12),Liangmen(ST21),Shangwan(RN 13),Xiawan(RN 10),Gongsun(SP4),Taibai(SP3),Zusanli(ST36),Jiexi(ST41),etc.,and makes adjustments according to the symptoms.It advocates a comfortable sensation from the needles,and properly tonifying and purging,aiming at regulating the spirit as a guide,reducing the stagnation of the liver qi,and tonifying the spleen and stomach.One test case is attached.

Abstract:Narcolepsy is a chronic sleep disorder disease,with the main clinical symptoms of daytime sleepiness,cataplexy,nighttime hallucinations,and sleep paralysis.Professor GUO Yi believes that the etiology and pathogenesis of narcolepsy are mainly based on spleen-kidney yang deficiency,with phlegm turbidity and blood stasis as manifestations.In terms of treatment,attention should be paid to warming and tonifying yang qi,resolving phlegm and removing blood stasis,and attaching importance to regulating emotions.The application of the"four dredging methods"—drugs to dredge the spleen and kidney by warming and tonifying the spleen and kidney,regulating qi and blood;acupuncture to dredge the heart and kidney by stimulating the heart-kidney connection and regulat-ing qi and strengthening the spleen,bloodletting to dredge the brain and refresh the mind by selecting the hand twelve Jing acupoints for puncture and bloodletting,and moxibustion to dredge the yang qi of the governor vessel and the whole body to warm the body's yang qi and achieve the effects of warming the governor vessel and awakening the spirit.

Abstract:Systematic sphygmology for pattern differentiation is a brand-new pulse science system that follows the fundamental principles and laws of systems theory,integrates clinical experience,and has unique insights.It encompasses multiple disciplines and covers multiple levels.It focuses on the development and differentiation of finger sensory functions,the establishment of a"scenario memory system"for various pulse element sensations,and the diagnosis and examination of objective"evidence chains"during the disease process,demonstrating characteristics such as systematicness,scientificity,standardization,practicality and ease of operation.However,the absence of operational specifications has hindered the clinical promotion and application as well as further innovative development of the pulse diagnosis technique of systematic sphygmology for pattern differentiation.This article,based on existing research findings,related literature on systematic sphygmology for pattern differentiation,and expert consensus,standardizes the techniques of systematic syndrome differentiation and pulse diagnosis from aspects such as pulse palpation,search and identification pulse information,analysis and generalization pulse information,aiming to promote the popularization and innovative develop-ment of the pulse diagnosis technique of systematic sphygmology for pattern differentiation.

Abstract:The formation of blood stasis begins with the deficiency of qi and blood due to consumptive disease,which leads to the lack of source and poor circulation of qi and blood.Deficiency and weakness,as well as blood stasis and dryness,generate dry blood.Subsequently,due to the steam and dampness of pathogenic heat,it evolves into chronic infectious disease,thus forming a transmission and transformation path of"consumptive disease-dry blood-chronic infectious disease".Based on the dominant position of the pathological elements of blood stasis in the generation,development and evolution of primary myelofibrosis,this article explores the pathogenesis and syndrome differentiation and treatment of primary myelofibrosis.It holds that the onset of the disease is based on internal deficiency and fatigue,the formation of the disease is often due to the internal formation of dry blood,and the transformation of the disease is due to internal consumption,which leads to chronic infectious disease.The treatment of this disease should take into account both strengthening the body's resistance and eliminating pathogenic factors.In the early stage of fibrosis,the basic treatment lies in streng-thening the body and clearing the source.During the obvious fibrosis stage,the treatment should focus on gradual recovery and tonifying deficiency.When the disease progresses and turns into leukemia,the key is to nourish yin and detoxify.One test case is attached.

Abstract:There are numerous types of skin diseases on the head and face.From the perspective of traditional Chinese medicine's physiological characteristics,the head and face are the convergence points of all yang qi,and the Yangming meridian is widely distributed.The vitality of the face depends on the prosperity and decline of the qi and blood in the yang meridians,especially the Yangming meridian.Excessive heat in the Yangming meridian is a common traditional Chinese medicine(TCM)syndrome type of head and facial skin diseases,and it is essentially consistent with excessive heat in the lung and stomach.Yunü Decoction(玉女煎)can clear excessive heat in the Yangming meridian and nourish the deficiency of water in the Shaoyin meridian.After clinical modification,it can be applied to the treatment of head and facial skin diseases.This article presents three test cases of Modified Yunü Decoction in the treatment of head and facial skin diseases,including acne,facial contact dermatitis,and rosacea.During the clinical diagnosis and treatment process,the main approach is to clear excessive heat in the Yangming meridian,while also taking into account nourishing yin,promoting blood circulation,eliminating dampness,and clearing the liver,which achieves remarkable therapeutic effects.

Abstract:"Dispersion can relieve congestion"refers to the treatment of congestion by promoting the circulation of qi through dispersing medicinals.This theory emphasizes promoting the circulation of qi,eliminating congestion,and restoring the normal body function.The main cause of prediabetes mellitus(PDM)lies in the obstruction of qi movement in the middle jiao and the accumulation of damp-heat.The treatment requires restoring the qi movement in the middle jiao,and promoting the circulation of qi is a key strategy.Starting from the theory of"dispersion can relieve congestion",this article classifies PDM into three syndrome types based on the intermingled characteristics of qi congestion,heat congestion and dampness stagnation:qi congestion combined with heat congestion,qi congestion combined with dampness congestion,and damp-heat combined with congestion.It proposes that the pungent and bitter medincals should be combined on the basis of the combination of property and flavor,combined with the therapeutic methods of unblocking the fu organs,promoting diuresis,aromatherapy and guiding stagnation,the proportion of medicinals should be adjusted according to the main contradiction to make congestion follow qi flow and congestion be eliminated to ensure smooth qi flow.In light of the relatively rigid status of PDM treatment,future research should start from the idea of combining pungent and bitter medincals and further explore the formulation techniques and medicinals selection of various schools in the Jin,Yuan,Ming and Qing Dynasties to optimize the treatment plan.

Abstract:Objective:To evaluate the efficacy and safety of premenstrual acupuncture and moxibustion stimulation of the Ren meridian in the treatment of primary dysmenorrhea(PD).Methods:This study adopted a prospective cohort design,with the expo-sure factor being whether the Ren meridian was stimulated.Eventually,108 patients with primary dysmenorrhea who received acupuncture and moxibustion treatment were included.According to the actual situation of the subjects receiving acupuncture and moxibustion treatment,they were divided into the Ren meridian group(73 cases)and the non-Ren meridian group(35 cases).The acupuncture method and acupoints are determined based on the patient's condition.The treatment was continued for three menstrual cycles,followed up for one menstrual cycle thereafter.The COX Menstrual Symptom Scale(CMSS)scores(including severity and duration)during the treatment period and the follow-up period were compared between the two groups.The scores of various traditional Chinese medicine(TCM)syndromes and the total scores of the two groups before and after treatment were compared.The short-term clinical efficacy and the clinical efficacy during the follow-up period of the two groups were compared.Results:During the first,second and third menstrual cycles of treatment and the follow-up period,the CMSS scores(severity and duration)of both groups decreased compared with those before treatment(P＜0.05).With the advancement of the treatment course,the CMSS scores(severity and duration)of both groups showed a decreasing trend(P＜0.01).During the follow-up period,the CMSS score(severity and duration)of the Ren meridian group was lower than that of the non-Ren meridian group(P＜0.05).Repeated measures analysis of variance was used to test the CMSS score data.The results showed that there was an interaction between exposure factors and time factors(P＜0.05),and both were important influencing factors of the CMSS score.However,there was no statistically significant difference in the analysis of the effects between the two subjects(P＞0.05).After treatment,each TCM syndrome score and total scores of both groups decreased compared with those before treatment(P＜0.01).After treatment,the TCM syndrome scores of whether there were blood clots,breast distension and pain,and scanty menstruation and total scores in the Ren meridian group were all lower than those in the non-Ren meridian group(P＜0.05).There was no statistically significant difference in the short-term clinical efficacy between the two groups(P＞0.05).The therapeutic effect of the Ren meridian group during the follow-up period was better than that of the non-Ren meridian group(P＜0.05).Conclusions:Premenstrual acupuncture and moxibustion stimulation of the Ren meridian has demonstrated excellent efficacy and high safety in the treatment of primary dysmenorrhea,providing high-quality real-world evidence for the clinical treatment of primary dysmenorrhea.

Abstract:Professor QI Yuanfu believes that the pathogenesis of triple-negative breast cancer(TNBC)is closely related to"liver Xuanfu-qi and fluid-nodules".The fundamental cause of TNBC is liver deficiency and stagnation.The disharmony of qi and fluid is the central link in the formation of TNBC,and the endogenous growth of nodules is the pathological outcome of the occurrence and development of TNBC.By analyzing the key pathogenesis of liver deficiency and stagnation,disharmony of qi and fluid,and internal generation of nodules in TNBC,as well as the evolution process of its pathogenesis from"deficiency and stagnation → qi depression → phlegm and blood stasis",it is proposed to treat TNBC with the general principle of"opening the liver Xuanfu and eliminating the mass".Based on the severity of the patient's deficiency and stagnation,qi depression,and phlegm and blood stasis,the Shiquan Yuzhen Decoction(十全育真汤)can be selected to support the body's healthy qi and open the liver Xuan,the Xiaoyao Loubei Powder(逍遥蒌贝散)to relieve depression and open the liver Xuan,the Chaishao Wendan Decoction(柴芍温胆汤)to eliminate phlegm and open the liver Xuanfu,and the Chaihu Sanleng Decoction(柴胡三棱汤)to remove blood stasis and open the liver Xuan.Additionally,wind medicinals with the function of ventilating liver and penetrating depression can be used to open the liver Xuanfu,and the medicinals with the function of eliminating phlegm,removing blood stasis,and unblocking nodules can be supple-mented to break through the nodules.One test case is attached.

Abstract:Objective:To explore the effects of Shihu Xiaowei Decoction(石斛消萎汤)combined with standard quadruple therapy on intestinal flora,oxidative stress and inflammatory factors in patients with chronic atrophic gastritis(CAG)complicated with gastric intestinal metaplasia(GIM).Methods:A total of 110 CAG patients complicated with GIM were selected and randomly divided into the western medicine group(treated with standard quadruple therapy)and the integrated traditional Chinese and western medicine group(treated with Shihu Xiaowei Decoction combined with standard quadruple therapy)according to the random number table method,with 55 cases in each group.The intestinal flora indexes,oxidative stress indexes,inflammatory factors,gastric function indexes,and gastric mucosal pathological scores before and after treatment were compared between the two groups.In addition,the clinical efficacy and incidence of adverse reactions were compared between the two groups.Results:After treatment,the levels of Lactobacillus,Bifidobacterium and superoxide dismutase(SOD)in both groups increased significantly compared with those before treatment,and the levels in the integrated traditional Chinese and western medicine group were higher than those in the western medicine group(P＜0.05).The levels of Enterococcus,Enterobacter,nitric oxide(NO),and malondialdehyde(MDA)were all lower than those before treatment,and the levels in the integrated traditional Chinese and western medicine group were lower than those in the western medicine group(P＜0.05).After treatment,the levels of interleukin-6(IL-6),Creactive protein(CRP),and tumor necrosis factor-α(TNF-α)in both groups were lower than those before treatment,and the levels in the integrated traditional Chinese and western medicine group were lower than those in the western medicine group(P＜0.05).After treatment,the levels of pepsinogen Ⅰ(PG Ⅰ)and pepsinogen ratio(PGR)in both groups increased compared with those before treatment,and the levels in the integrated traditional Chinese and western medicine group were higher than those in the western medicine group(P＜0.05).The level of pepsinogen Ⅱ(PG Ⅱ)was lower than that before treatment,and the level of the integrated traditional Chinese and western medicine group was lower than in the western medicine group(P＜0.05).After treatment,the GIM,gastric mucosal atrophy and mucosal inflammation scores of both groups were lower than those before treatment,and the scores of the integrated traditional Chinese and western medicine group were lower than those of the western medicine group(P＜0.05).The total effective rate of treatment of the integrated traditional Chinese and western medicine group(94.55％)was higher than that of the western medicine group(80.00％)(P＜0.05).The total incidence of adverse reactions in the integrated traditional Chinese and western medicine group was 7.27％,which was lower than 23.64％in the western medicine group(P＜0.05).Conclusion:Shihu Xiaowei Decoction combined with standard quadruple therapy has a better therapeutic effect in the treatment of CAG complicated with GIM.It can inhibit oxidative stress response and inflammatory factors,maintain the balance of intestinal flora,protect gastric mucosa,improve gastric function indexes and reduce the incidence rate of adverse reactions.