Progress of ABCG2 in Obstetrics

JIA Yan-ju; CUI Hong-yan

Abstract：ATP-Binding Cassette Family G2 Transporters (ABCG2) is one of the active transporters in the placenta. It can not only resist the drugs entering cells, but also transport a variety of harmful toxic chemicals away from body. The physiological function of ABCG2 is likely to protect tissues from endogenous toxin or different xenobiotics and remain the cellular environmental homeostasis, ABCG2 is highly expressed in human placenta,it is located in the apical membrane of syncytiotrophoblast cell facing the mother side and form a barrier effectively in the maternal-fetal interface, limiting drugs, endogenous toxin and xenobiotics which possibly affect the fetus through the placenta. ABCG2 is also participate in the differentiation of placenta and cell apoptosis and some complications of pregnancy such as preeclampsia, gestational diabetes, chorioamnionitis and fetal growth restriction, etc. As a drug transporter, ABCG2 is related to the therapy of these complications during pregnancy. It is important to know more about ABCG2 for its important clinical significance. The structure and function of the ABCG2 and its roles in the field of obstetrics were reviewed in this paper.