Protective effect of Zhitangshu on tissue of type 2 diabetes rats to peroxidation injury

doi:10.3321/j.issn:1673-8225.2003.24.021

Abstract：AIM:To observe the protective effect of Zhitangshu on tissue of type 2 diabetes rats to peroxidation injury. METHODS:Rat model of type 2 diabetes was established by abdominal injection of small dosage of streptozotocin combined with high calorie feeding.Metformin,gliclazide and Zhitangshu in different dosages were respectively perfused into stomach for 9 weeks and healthy rats were used as control.Levels of blood glucose,blood- lipid and blood insulin and other indexes were detected.Thereafter,rats were sacrificed and the content of malonic aldehyde(MDA) and activities of superoxide dismutase(SOD) in heart,liver,pancreas and brain were measured. RESULTS:Zhitangshu,Metformin and gliclazide could significantly reduce MDA content and increase SOD activity in above tissue(P< 0.05 or P< 0.01 in model group.The effect of Zhitangshu in a large dosage in reducing liver MDA was superior to that of gliclazide(P< 0.05) and the effect of Zhi tangshu in reducing pancreas MDA was superior to that of small dosage group(P< 0.01).There were no significant differences between other groups in MDA contents and activities in tissue(P >0.05),suggesting that Zhitangshu had the same protective effect as Metformin and gliclazide on tissues to peroxidization injury. CONCLUSION:Zhitangshu has significant protective effect on tissue of type 2 diabetes rats to peroxidation injury.