Effect of estrogen on symptoms related with depression in peri-menopausal women

doi:10.3321/j.issn:1673-8225.2004.30.021

Abstract：BACKGROUND: It has been proved that estrogen decreases the occurrence of osteoporosis in menopausal women. Does estrin treatment have the function of improving the symptoms related with depression in peri-menopausal women?OBJECTIVE: To observe the effect of estrogen on the symptoms related with depression in peri-menopausal women.DESIGN: A case-controlled study.SETTING and PARTICIPANTS: Totally 60 peri-menopausal patients complaining of symptoms of depression in the Out-patient Clinic, Department of Obstetrics & Gynecology of Shandong Provincial Hospital were selected. They were required to be sane, cooperative and consented to administration of medicines and evaluation according to the rules and with the age of (45 -55) years.INTERVENTIONS: The 60 depressive patients in the peri-menopausal period were randomly divided into two groups, 30 in each. The experiment group received 1 mg progynova (Guangzhou Xianling Pharmacy Co. Ltd., qualification No. 588B2-4)and 10 mg gammariza(Jining Ankang Pharmacy Co. Ltd, Qualification No. 010418) three time per day; The control group received 10 mg gammariza three times per day. The course was 21 days. The depressive degree was assessed by Hamilton Rating Scales for Depression(HAMD) before and after treatment.MAIN OUTCOME MEASURES: The improvement of depression of patients in the two groups before and after administration.RESULTS: Decreased rate of HAMD in the experimental group [(59.8±7.7)%] was significantly higher than that of the control group [(15.3±5.4)%], and the differences had significant meaning(t = 25. 924, P ＜ 0.01); Effect of anti depression was significantly better than that in the control group(26 cases showed effect in the experimental group, 3in the control group), and the difference had significant meaning(x2= 35. 312, P＜0.01).CONCLUSION: Eestrogen can improve the emotion and behavior of depressive peri-menopausal patievts,dedrease depression value and ameliorate depressie status.