Experimental study of Shensongyangxin capsule plus Tongxinluo capsule on rabbit cardiac electrophysiology in merid- ians intervention
Abstract：Objective To observe the effect of Shensongyangxin capsule plus Tongxinluo capsule on cardiac electro-physiological properties in Japanese big ear rabbit with myocardial infarction model , and investigate the mechanism of treat-ment after myocardial infarction arrhythmia .Methods Twenty-four Japanese big ear rabbits were randomly divided into sham operation group and model group , Tongluo group with 8 rats in each group , before descending artery ligation to establish the model of myocardial infarction , Tongluo group were given 0.4 g· kg-1 · d-1 of Shensongyangxin powder +0.3 g· kg-1 · d-1 Tongxinluo powder through gastric lavage after the ligation of descending artery .After 8 weeks, in vivo electrophysiology were performed .Results Compared with the sham operation group , model group ’ s left ventricle adventitia myocardial cell action potential duration of 90%repolarization time (MAPD 90) is shortened ( P <0.05); left ventricular MAPD 90 also is shortened ( P <0.05);left ventricular effective refractory period (ERP) is prolonged ( P <0.05); ventricular fibrillation (VF) threshold (VFT) decreased significantly ( P <0.05).Compared with the model group,Tongluo group’s left ventricular adventitia myocardial cells MAPD 90 is prolonged;left ventricular MAPD 90 is prolonged ( P <0.05);ERP is shortened (P <0.05);VFT is increased significantly ( P <0.05).Conclusion The Shensongyangxin capsule plus Tongxinluo capsule could prolong MAPD 90 and shorten the ERP ,play the antiarrhythmic effect by increasing VFT after myocardial infarction .
Keywords：Shensongyangxin capsuleTongxinluo capsuleMyocardial infarctionElectrophysiologyRabbit
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1058-1061 )