The effect of Qiliqiangxin capsule on heart function in the patients with chronic renal failure combined with chronic congestive heart failure
ZHANG Ran
ZHANG Li
ZHANG Jiwei
TIAN Ling
LI Xiangxin
Abstract：Objective To observe the effect of Qiliqiangxin capsule on plasma brain natriuretic peptide (BNP),C-reactive protein ( CRP) and cardiac function in patients with chronic renal failure and chronic congestive heart failure. Metho-ds Eighty patients with chronic renal failure and chronic congestive heart failure were randomly divided into control group and study group with 40 cases in each group. 2 groups were treated with routine application of diuretics , angiotensin-converting en-zyme inhibitors, beta blockers, nitrates, digitalis drug treatment, the study group also received Qiliqiangxin capsule 4 grain, 3 times /d.Before and 8 weeks after treatment , plasma BNP and the expression level of CRP and left ventricular end diastolic volume ( LVEDV) , left ventricular end systolic volume ( LVESV ) , left ventricular end diastolic diameter ( LVEDD ) , left ventricular ejection fraction (LVEF) changes were observed and compared between the 2 groups.Results The effective rate in the study group was better than that in control group (82.5% vs.65.0%, P <0.05).Before treatment, plasma BNP, CRP level and LVEDV, LVESV, LVEDD, LVEF in the 2 groups revealed no significant differences ( P >0.05).Compared with before treatment, plasma BNP and CRP levels after 8 weeks were decreased in both of the two groups ( P <0.05), LV-EDV, LVESV, LVEDD, LVEF were improved ( P <0.05).Compared with the control group , levels of serum BNP, CRP were decreased significantly ( P <0.05) and the heart function improved significantly in the study group (P <0.05).Con-clusion It demonstrated that the Qiliqiangxin capsule could significantly decrease the expression level of plasma BNP and CRP in patients with the chronic renal failure and chronic congestive heart failure; it can improve the heart function and the clinical treatment effect.
Keywords：Renal failurechronicHeart failurecongestiveQiliqiangxin capsuleHeart function
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1279-1282 )