Meta-analysis on the treatment of meglumine cyclic adenylate for sick sinus syndrome
LI Le
TANG Yanhong
YU Taihui
WANG Dandan
Abstract：Objective To systematic evaluate the therapeutic effect of meglumine adenosine cyclophosphate for treat-ment of patients with sick sinus syndrome. Methods Computer retrieval PubMed, CENTRAL, EMbase, the ISI Web of Knowledge Databases,VIP,CNKI,CBM and Wanfang database to collect the randomized controlled trials of meglumine adeno-sine cyclophosphate for treatment of sick sinus syndrome, data were collected from 1999 January to 2013 December. According to the inclusion and exclusion criteria, extraction and quality evaluation of screening RCT data were performed by 2 observer independently;statistical analysis was performed using RevMan5. 2 software. Results 13 study of 1 119 patients were included, the Meta-analysis results showed that:compared with the control group, meglumine cyclic adenosine for sick sinus syndrome can improve the total efficiency (OR=7. 29, 95%CI 5. 42-9. 81, P <0. 01), increased the 24 h’s total heart rate (SMD=4.74,95%CI4.42-5.06,P <0.01) andtheaverageheartrate(MD=11.56,95%CI10.79 -12.33,P <0.01), shorten the sinus node recovery time (SNRT) (SMD= -1. 49, 95%CI -1. 65 to -1. 33, P <0. 01) and sinoatrial conduc-tion time (SACT) (MD= -85. 39, 95%CI -90. 22 to -80. 56, P <0. 01). Conclusion Meglumine cyclic adenosine in treating of sick sinus syndrome can significantly improve the clinical symptoms and cardiac function as increase the 24 h’ s to-tal heart rate and average heart rate, shorten the sinus node recovery time and sinoatrial conduction time.
Keywords：Meglumine adenosine cyclophosphateSick sinus syndromeRandomized controlled trialsMeta analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 185-190 )