The research progress of the association between polymorphisms in ADAM33 gene with COPD and lung function
SHAO Lu
JIA Yanyun
Abstract：The pathogenesis of COPD is a multifactorial process including inflammatory cell profile, relevant with individual factors,environmental factors and genetic factors. ADAM33 gene has selectively expressed in mesenchymal cells, participates in the airway remodeling process, which has been identified as an asthma susceptible gene and high reactivity related genes. Recent studies revealed that single nucleotide polymorphisms (SNPs) within ADAM33 increased the suscepti-bility to COPD through changing the airway inflammatory process and lung function by making organisms susceptible to certain environmental factor. Therefore,in order to understand the role of ADAM33 gene in the process of lung function decline in COPD,contribute to the treatment of this disease, ADAM33' SNPS and it's the impact on COPD pulmonary function reviewed.
Keywords：ADAM33Chronic obstructive pulmonary diseaseSingle nucleotide polymorphismLung function
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 420-423 )