Influences of Atorvastatin in different doses on atherogenic index of plasma and outcomes in patients with acute myocardial infarction
BAO Feng-mei
MA Wei-li
ZHANG Li-li
Abstract：Objective To investigate the influences of Atorvastatin on atherogenic index of plasma and (AIP) and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI).Methods A total of 212 patients diagnosed as AMI in our department were randomly divided into two groups:the standard group (n=106) and the intensive group (n=106).Both group patients were given basic treatment of AMI.Patients in the standard group were given Atorvastatin (20 mg/d) and patients in the intensive group were given Atorvastatin(40 mg/d).Blood lipid,AIP and pulse wave velocity(PWV) were evaluated after 1 years' therapy.At the same time,the incidence of MACE were recorded.Results Relation analysis showed that AIP level was positively correlated with PWV (r=0.801,P＜0.05).After 1 years' treatment,the AIP were decreased in both group patients[before treatment (0.34±0.06) vs after treatment (0.22±0.05),P＜0.05] and [before treatment (0.33±0.06) vs after treatment(0.17±0.05),P＜0.05],and the changes were more marked in intensive group [at standard group (0.22±0.05) vs at intensive group (0.17±0.05),P＜0.05].The intima-media thickness in the intensive treatment group was significantly lower than that before treatment [before treatment (1.41 ±0.18)mm vs after treatment (1.10± 0.17)mm,P＜0.05].After 1 years' treatment,the incidence of MACE was lower in intensive group than that in standard group (at standard group 22.64％ vs at intensive group 11.32％,P＜0.05) Conclusion The intensive treatment of Atorvastatin can significantly reduced AIP levels and MACE in the patients with AMI.
Keywords：Acute myocardial infarctionAtherosclerosisAtherogenic index of plasmaPulse wave velocityMajor adverse cardiovascular events
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 945-949 )